Ankyrin domains across the Tree of Life.
Ankyrin domains across the Tree of Life.
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作者：
Jernigan KK;Bordenstein SR
锚蛋白（ANK）重复序列是最常见的氨基酸序列基序之一，介导无数大小，形状和功能的蛋白质之间的相互作用。我们首次评估了它们在细菌和古细菌中的广泛丰度，并在细菌中证明了生活方式，而不是系统发育历史，是ANK重复丰度的预测因子。与自由生活的细菌相比，与真核生物形成兼性和专性共生的不相关生物显示出ANK重复序列的富集。专性细胞内细菌的减少基因组明显比其他生活方式含有更高比例的ANK重复蛋白，并且与其他细菌相比，每种蛋白质中ANK重复的数量增加。综上所述，这些结果重新评估了ANK重复序列是真核蛋白特征的概念，并支持了细胞内细菌广泛使用ANK重复序列与真核宿主细胞的结构-功能关系的假设。
Ankyrin (ANK) repeats are one of the most common amino acid sequence motifs that mediate interactions between proteins of myriad sizes, shapes and functions. We assess their widespread abundance in Bacteria and Archaea for the first time and demonstrate in Bacteria that lifestyle, rather than phylogenetic history, is a predictor of ANK repeat abundance. Unrelated organisms that forge facultative and obligate symbioses with eukaryotes show enrichment for ANK repeats in comparison to free-living bacteria. The reduced genomes of obligate intracellular bacteria remarkably contain a higher fraction of ANK repeat proteins than other lifestyles, and the number of ANK repeats in each protein is augmented in comparison to other bacteria. Taken together, these results reevaluate the concept that ANK repeats are signature features of eukaryotic proteins and support the hypothesis that intracellular bacteria broadly employ ANK repeats for structure-function relationships with the eukaryotic host cell.
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影响因子：
15.9
作者：
Al-Khodor S;Price CT;Kalia A;Abu Kwaik Y
通讯作者：
Abu Kwaik Y
影响因子：
4.4
作者：
Fan Y;Thompson JW;Dubois LG;Moseley MA;Wernegreen JJ
通讯作者：
Wernegreen JJ
影响因子：
3.4
作者：
IJdo, Jacob W.;Carlson, Adam C.;Kennedy, Elizabeth L.
通讯作者：
Kennedy, Elizabeth L.
影响因子：
2.9
作者：
Inada H;Procko E;Sotomayor M;Gaudet R
通讯作者：
Gaudet R
DOI：
10.1002/prot.340170405
发表时间：
1993-12-01
期刊：
PROTEINS-STRUCTURE FUNCTION AND GENETICS
影响因子：
--
作者：
BORK, P
通讯作者：
BORK, P