Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.
Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.
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DOI：
10.1289/ehp.5715
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发表时间：
2003-09
影响因子：
10.4
通讯作者：
Koppe JG
中科院分区：
文献类型：
--
作者：
ten Tusscher GW;Steerenberg PA;van Loveren H;Vos JG;von dem Borne AE;Westra M;van der Slikke JW;Olie K;Pluim HJ;Koppe JG
1990 年荷兰“背景”二恶英水平的围产期暴露水平很高，但与其他西欧工业化国家相当。在敏感的围产期接触可能会造成永久性的障碍。因此，我们评估了纵向队列中的健康状况以及各种血液学和免疫学参数。研究人员对 27 名记录有围产期二恶英暴露记录的 8 岁健康儿童进行了纵向队列记录，并对其进行了病史记录和静脉穿刺。线性回归显示，与产前（p = 0.02）和产后（p = 0.03）二恶英暴露相关的过敏减少。 CD4+ T 辅助细胞 (p = 0.006) 和 CD45RA+ 细胞 (p = 0.02) 的增加与出生后暴露有关。血小板计数持续减少（p = 0.04）和血小板生成素浓度增加（p = 0.03）与产后暴露有关。该随访显示过敏减少、血小板持续减少、血小板生成素增加、CD4+ T 辅助细胞和 CD45RA+ 细胞计数增加。这项研究提供了围产期二恶英暴露对干细胞水平的影响的迹象，这种影响至少持续到出生后 8 年。
Perinatal exposure to Dutch "background" dioxin levels in 1990 was high, but comparable with that of other industrialized Western European countries. Exposure during the sensitive perinatal period may cause permanent disturbances. Therefore, we assessed the health status and various hematologic and immunologic parameters among our longitudinal cohort. A medical history was taken and venipuncture performed in a longitudinal cohort of 27 healthy 8-year-old children who had documented perinatal dioxin exposure. Linear regression revealed a decrease in allergy in relation to prenatal (p = 0.02) and postnatal (p = 0.03) dioxin exposure. Increases in CD4+ T-helper cells (p = 0.006) and in CD45RA+ cells (p = 0.02) were seen in relation to postnatal exposure. A persistently decreased platelet count (p = 0.04) and increased thrombopoietin concentration (p = 0.03) were seen in relation to postnatal exposure. This follow-up has shown a decrease in allergy, persistently decreased thrombocytes, increased thrombopoietin, and increased CD4+ T-helper and increased CD45RA+ cell counts. This study provides indications of effects at the stem cell level of perinatal dioxin exposure, persisting until minimally 8 years after birth.
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影响因子：
17.3
作者：
KOPPE, JG;OLIE, K;PLUIM, E
通讯作者：
PLUIM, E
影响因子：
3.8
作者：
Murante, FG;Gasiewicz, TA
通讯作者：
Gasiewicz, TA
影响因子：
5.8
作者：
SHIVERICK, KT;MUTHER, TF
通讯作者：
MUTHER, TF
影响因子：
8.8
作者：
Nagayama, J;Tsuji, H;Watanabe, T
通讯作者：
Watanabe, T
影响因子：
8.8
作者：
KROWKE, R;ABRAHAM, K;NEUBERT, D
通讯作者：
NEUBERT, D