Hyperpolarized carbon 13 MRI in liver diseases: Recent advances and future opportunities.

Hyperpolarized carbon 13 MRI in liver diseases: Recent advances and future opportunities.
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DOI:
10.1111/liv.15222
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发表时间:
2022-05
影响因子:
6.7
通讯作者:
Laustsen, Christoffer
Laustsen, Christoffer
中科院分区:
医学2区
文献类型:
--
作者:
Ye, Zheng;Song, Bin;Lee, Philip M.;Ohliger, Michael A.;Laustsen, Christoffer

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超极化碳- 13磁共振成像(hp13c MRI)是一种最新的代谢成像技术。通过溶解动态核极化(d - DNP),可以很容易地达到超过10,000倍的信号增强,从而可以在注射碳- 13标记探针后可视化肝脏中的实时代谢和特定底物到代谢物的转化。越来越多的证据表明,hp13c MRI是检测肝脏异常、预测疾病进展和监测治疗反应的潜在工具。本文将介绍HP 13C MRI在弥漫性肝脏疾病和肝脏恶性肿瘤中的最新进展,并从临床角度探讨其未来的发展机会,以期全面概述这项新技术在肝脏疾病中的应用,突出其在肝病学领域的科学和临床潜力。
Hyperpolarized carbon‐13 magnetic resonance imaging (HP 13C MRI) is a recently translated metabolic imaging technique. With dissolution dynamic nuclear polarization (d‐DNP), more than 10 000‐fold signal enhancement can be readily reached, making it possible to visualize real‐time metabolism and specific substrate‐to‐metabolite conversions in the liver after injecting carbon‐13 labelled probes. Increasing evidence suggests that HP 13C MRI is a potential tool in detecting liver abnormalities, predicting disease progression and monitoring response treatment. In this review, we will introduce the recent progresses of HP 13C MRI in diffuse liver diseases and liver malignancies and discuss its future opportunities from a clinical perspective, hoping to provide a comprehensive overview of this novel technique in liver diseases and highlight its scientific and clinical potential in the field of hepatology.
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