Cyclotron production and radiochemical separation of (55)Co and (58m)Co from (54)Fe, (58)Ni and (57)Fe targets.
Cyclotron production and radiochemical separation of (55)Co and (58m)Co from (54)Fe, (58)Ni and (57)Fe targets.
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DOI：
10.1016/j.apradiso.2017.09.005
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Nickles RJ
中科院分区：
文献类型：
--
作者：
Valdovinos HF;Hernandez R;Graves S;Ellison PA;Barnhart TE;Theuer CP;Engle JW;Cai W;Nickles RJ
用回旋加速器对电镀靶进行强电流（40 μA p和60 μA d）辐照，通过54 Fe（d，n）和58 Ni（p，α）反应产生正电子发射体55 Co，通过57 Fe（d，n）反应产生俄歇电子发射体58 mCo。高比活度放射性核素（高达55.6 GBq/μmol 55 Co和31.8 GBq/μmol 58 mCo），具有高放射性核素纯度（在轰击结束时，EoB，54 Fe中的55 Co为99.995%，58 Ni中的55 Co为98.8%，57 Fe中的58 mCo为98.7%），在高活性浓度下（最终分离的放射性核素< 0.6 mL），并且具有几乎定量的总活性分离产率（> 92%）采用基于HCl溶解和树脂N，N，N′，N′-四-2-乙基己基二甘醇酰胺（DGA，branched）的新型放射化学分离方法对辐照靶进行处理后，得到了100 - 200 μ mol/L的100 - 100 μ mol/L的100 - 100 μ mol使用38-65、110-214和59-78 mg富集的54 Fe进行1小时长的辐照（99.93%），58Ni（99.48%）和57 Fe（95.06%），在1.0cm ~ 2表面上电镀，分别产生582 ± 66 MBq ~（55）Co、372 ± 14 MBq ~（55）Co和810 ± 186 MBq ~（58）mCo，衰减校正为EoB。分离方法允许回收昂贵的富集靶材料，这些材料在新的电镀方法后重新组合成金属靶，铁的总回收效率为93 ± 4%。所产生的放射性核素用于放射性标记与螯合剂NOTA缀合的血管生成标志物抗体TRC 105，以证明其质量。
This work presents the production with a cyclotron of the positron emitter 55Co via the 54Fe(d,n) and 58Ni(p,α) reactions and the Auger electron emitter 58mCo via the 57Fe(d,n) reaction after high current (40 μA p and 60 μA d) irradiation on electroplated targets. High specific activity radionuclides (up to 55.6 GBq/μmol 55Co and 31.8 GBq/μmol 58mCo) with high radionuclidic purity (99.995% 55Co from 54Fe, 98.8% 55Co from 58Ni, and 98.7% 58mCo from 57Fe at end of bombardment, EoB), in high activity concentration (final separated radionuclide in < 0.6 mL) and with almost quantitative overall activity separation yield (> 92%) were obtained after processing of the irradiated targets with novel radiochemical separation methods based on HCl dissolution and the resin N,N,N′,N′-tetrakis-2-ethylhexyldiglycolamide (DGA, branched). One hour long irradiations using 38–65, 110–214 and 59–78 mg of enriched 54Fe (99.93%), 58Ni (99.48%) and 57Fe (95.06%), respectively, electroplated over a 1.0 cm2 surface, yielded 582 ± 66 MBq 55Co, 372 ± 14 MBq 55Co and 810 ± 186 MBq 58mCo, respectively, decay corrected to EoB. The separation methods allow for the recovery of the costly enriched target materials, which were reconstituted into metallic targets after novel electroplating methods, with an overall recycling efficiency of 93 ± 4% for iron. The produced radionuclides were used to radiolabel the angiogenesis marker antibody TRC105 conjugated to the chelator NOTA as a demonstration of their quality.
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