PRESENCE OF PUPS SUPPRESSES HUNGER-INDUCED FEEDING IN VIRGIN ADULT MICE OF BOTH SEXES
PRESENCE OF PUPS SUPPRESSES HUNGER-INDUCED FEEDING IN VIRGIN ADULT MICE OF BOTH SEXES
复制标题
幼崽的存在抑制了两性处女成年小鼠的饥饿引起的进食
DOI：
10.1016/j.neuroscience.2017.08.047
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发表时间：
2017-10
期刊：
影响因子：
3.3
通讯作者：
Xu Xiao-Hong
中科院分区：
文献类型：
--
作者：
Han Ying;Li Xing-Yu;Wang Shao-Ran;Wei Yi-Chao;Xu Xiao-Hong
尽管最近在个体行为背后的神经通路方面取得了进展，但动物如何平衡和优先考虑行为输出仍然知之甚少。在研究饥饿诱导的喂养和幼鼠诱导的雌性行为之间的关系时，我们意外地发现幼鼠的存在强烈延迟和减少了食物消耗。引人注目的是，幼崽的存在也抑制了由Agrp神经元的光遗传学激活诱导的进食。这种抑制作用与母性行为的程度呈负相关，但不依赖于这些行为的显示，并且也存在于处女男性中。此外，化学发生激活VEGF2+神经元的内侧视前区（mPOA），一个地区的关键母亲的行为和动机，足以抑制饥饿诱导的喂养。然而，蝇蕈醇抑制的mPOA，同时破坏母体行为，并没有阻止幼崽抑制喂养，表明在其他脑区的神经通路也可能介导这样的效果。总之，这些结果提供了新的见解，神经协调的小狗护理和喂养的小鼠和组织的动物行为一般。
Despite recent progress on neural pathways underlying individual behaviors, how an animal balances and prioritizes behavioral outputs remains poorly understood. While studying the relationship between hunger-induced feeding and pup-induced maternal behaviors in virgin female mice, we made the unexpected discovery that presence of pups strongly delayed and decreased food consumption. Strikingly, presence of pups also suppressed feeding induced by optogenetic activation of Agrp neurons. Such a suppressive effect inversely correlated with the extents of maternal behaviors, but did not rely on the display of these behaviors, and was also present in virgin males. Furthermore, chemogenetic activation of Vglut2+ neurons in the medial preoptic area (mPOA), a region critical for maternal behaviors and motivation, was sufficient to suppress hunger-induced feeding. However, muscimol inhibition of the mPOA, while disrupting maternal behaviors, did not prevent pup suppression of feeding, indicating that neural pathways in other brain regions may also mediate such an effect. Together, these results provide novel insights into neural coordination of pup care and feeding in mice and organizations of animal behaviors in general.
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