Why meals during resting time cause fat accumulation in mammals? Mathematical modeling of circadian regulation on glucose metabolism
Why meals during resting time cause fat accumulation in mammals? Mathematical modeling of circadian regulation on glucose metabolism
复制标题
为什么休息时间进餐会导致哺乳动物脂肪堆积？
DOI：
10.1007/s00285-021-01645-8
复制
发表时间：
2021
影响因子：
1.9
通讯作者：
Satake Akiko
中科院分区：
文献类型：
--
作者：
Hara Akane;Satake Akiko
由生物钟和进餐时间调节的代谢节律的同步对于维持营养稳态以应对动物食物摄入的波动至关重要。尽管有大量关于昼夜节律调节葡萄糖和脂质代谢的实验结果，但维持能量稳态的最佳调节策略仍然不明确。数学框架可用于通过评估日依赖性激活的时间或每个代谢过程的抑制在维持能量稳态中的贡献来评估糖原产生/分解和从头脂肪生成/脂肪分解的昼夜节律调节。在这里，我们提出了一个数学模型，描述了糖原和甘油三酯含量的动态，这是体内能量储存的两种主要形式，在食物匮乏的不同阶段提供所需的燃料。通过改变糖生成和脂肪合成的峰值阶段，我们寻找最佳的阶段集，以最大限度地降低两种可能的代谢功能障碍的风险：（1）高血糖和（2）能量耗尽。根据最佳阶段设置，我们比较了活动期和休息期进餐时间之间的脂肪积累水平。我们的结果表明，在动物在自然界中采用的同步喂养计划中，休息期间食物摄入增加的脂肪积累可能是最小化能量稳态风险的副产品。我们的发现将有助于安排最佳进餐时间，以预防现代社会因生物时间和社会时间错位而引起的代谢疾病。
Synchronization of metabolic rhythms regulated by circadian clock and meal timing is essential for maintaining nutrient homeostasis in response to fluctuating food intake in animals. Despite numerous experimental findings on the involvement of circadian regulation of glucose and lipid metabolism, the optimal regulatory strategy for the maintenance of energy homeostasis remains poorly defined. A mathematical framework is useful to assess the circadian regulation of glycogen production/breakdown and de novo lipogenesis/lipolysis by evaluating the contribution of time of the day-dependent activation or the repression of each metabolic process in the maintenance of energy homeostasis. Here, we present a mathematical model that describes the dynamics of glycogen and triglyceride contents, two major forms of energy storage in the body that provide the fuel needed during different phases of food deprivation. By changing peak phases of glycogenesis and fat synthesis, we searched for the optimal phase set that minimizes the risks of two types of possible metabolic dysfunctions: (1) high blood glucose and (2) energy exhaustion. Based on the optimal phase set, we compared the level of fat accumulation between meal timing in the active and resting periods. Our results showed that an increased fat accumulation by food intake in the resting period can be the byproduct of minimizing energy homeostasis risks in the synchronized feeding schedule that animals adopt in nature. Our finding will be useful to schedule an optimal meal timing to prevent metabolic diseases caused by misalignment of biological and social time in modern society.
登录
查看更多内容
DOI：
10.1093/occmed/kqr001
发表时间：
2011-03
期刊：
Occupational medicine (Oxford, England)
影响因子：
--
作者：
Wang XS;Armstrong ME;Cairns BJ;Key TJ;Travis RC
通讯作者：
Travis RC
影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
使用荧光花青染料对青蛙角膜进行电生理学研究。
DOI：
10.1152/ajpcell.1980.238.1.c21
发表时间：
1980
期刊：
The American journal of physiology
影响因子：
--
作者：
C. Graves;G. Sachs;W. S. Rehm
通讯作者：
W. S. Rehm
影响因子：
29
作者：
Adamovich Y;Rousso-Noori L;Zwighaft Z;Neufeld-Cohen A;Golik M;Kraut-Cohen J;Wang M;Han X;Asher G
通讯作者：
Asher G
影响因子：
--
作者：
ISHIKAWA, K;SHIMAZU, T
通讯作者：
SHIMAZU, T