Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO.
Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO.
复制标题
DOI：
10.1016/j.envres.2020.110320
复制
发表时间：
2021-05
影响因子：
8.3
通讯作者：
Environmental influences on Child Health Outcomes
中科院分区：
文献类型：
--
作者：
Volk HE;Perera F;Braun JM;Kingsley SL;Gray K;Buckley J;Clougherty JE;Croen LA;Eskenazi B;Herting M;Just AC;Kloog I;Margolis A;McClure LA;Miller R;Levine S;Wright R;Environmental influences on Child Health Outcomes
空气污染暴露无处不在，已证实对发病率和死亡率有影响。越来越多的文献表明，产前接触空气污染会影响神经发育。我们认为，考虑到 ECHO 参与者广泛的时空变化，环境对儿童健康结果的影响 (ECHO) 计划将为填补关键知识空白提供独特的机会。我们简要描述了当前空气污染暴露评估的方法，总结了空气污染和神经发育的现有研究，并综合这些信息作为建议或蓝图的基础，以评估空气污染对 ECHO 神经发育结果的影响。我们回顾了有关产前空气污染暴露和神经发育结果的同行评审文献，包括自闭症谱系障碍、注意力缺陷多动障碍、智力、一般认知、情绪和影像测量。编译和评估 ECHO 元数据，以评估神经发育评估的频率以及产前和婴儿期的居住地址位置。总结了队列招募地点和入学年份，以检查 ECHO 中存在的潜在空间和时间变化。虽然文献提供了令人信服的证据表明产前空气污染会影响神经发育，但当前发表的研究存在空间和时间暴露变化的局限性。由于超过 90% 的 ECHO 队列收集了产前或婴儿期地址，因此应用基于先进地理信息系统的常见空气污染物暴露模型可能是解决已发表研究局限性的理想选择。在 ECHO，我们有机会率先统一暴露评估，评估多个发育时期和神经发育结果的影响，制定产前空气污染暴露评估标准，以改善儿童的健康。
Air pollution exposure is ubiquitous with demonstrated effects on morbidity and mortality. A growing literature suggests that prenatal air pollution exposure impacts neurodevelopment. We posit that the Environmental influences on Child Health Outcomes (ECHO) program will provide unique opportunities to fill critical knowledge gaps given the wide spatial and temporal variability of ECHO participants. We briefly describe current methods for air pollution exposure assessment, summarize existing studies of air pollution and neurodevelopment, and synthesize this information as a basis for recommendations, or a blueprint, for evaluating air pollution effects on neurodevelopmental outcomes in ECHO. We review peer-reviewed literature on prenatal air pollution exposure and neurodevelopmental outcomes, including autism spectrum disorder, attention deficit hyperactivity disorder, intelligence, general cognition, mood, and imaging measures. ECHO meta-data were compiled and evaluated to assess frequency of neurodevelopmental assessments and prenatal and infancy residential address locations. Cohort recruitment locations and enrollment years were summarized to examine potential spatial and temporal variation present in ECHO. While the literature provides compelling evidence that prenatal air pollution affects neurodevelopment, limitations in spatial and temporal exposure variation exist for current published studies. As >90% of the ECHO cohorts have collected a prenatal or infancy address, application of advanced geographic information systems-based models for common air pollutant exposures may be ideal to address limitations of published research. In ECHO we have the opportunity to pioneer unifying exposure assessment and evaluate effects across multiple periods of development and neurodevelopmental outcomes, setting the standard for evaluation of prenatal air pollution exposures with the goal of improving children’s health.
登录
查看更多内容
DOI：
10.1038/nrendo.2016.186
发表时间：
2017-03
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Braun JM
通讯作者：
Braun JM
影响因子：
10.4
作者：
Dalgard C;Grandjean P;Jorgensen PJ;Weihe P
通讯作者：
Weihe P
影响因子：
2.1
作者：
Alexeeff, Stacey E.;Carroll, Raymond J.;Coull, Brent
通讯作者：
Coull, Brent
影响因子：
5.2
作者：
Baeumer, Dominique;Vogel, Bernhard
通讯作者：
Vogel, Bernhard
影响因子：
9.3
作者：
Cheng H;Davis DA;Hasheminassab S;Sioutas C;Morgan TE;Finch CE
通讯作者：
Finch CE