Mechanisms of cell competition: themes and variations.
Mechanisms of cell competition: themes and variations.
复制标题
细胞竞争的机制:主题和变化。
DOI:
10.1083/jcb.201301051
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发表时间:
2013-03-18
期刊:
影响因子:
--
通讯作者:
Moreno E
中科院分区:
文献类型:
--
作者:
Levayer R;Moreno E
Cell competition is the short-range elimination of slow-dividing cells through apoptosis when confronted with a faster growing population. It is based on the comparison of relative cell fitness between neighboring cells and is a striking example of tissue adaptability that could play a central role in developmental error correction and cancer progression in both Drosophila melanogaster and mammals. Cell competition has led to the discovery of multiple pathways that affect cell fitness and drive cell elimination. The diversity of these pathways could reflect unrelated phenomena, yet recent evidence suggests some common wiring and the existence of a bona fide fitness comparison pathway.
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DOI:
10.1073/pnas.1113882109
发表时间:
2012-01-10
影响因子:
11.1
作者:
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通讯作者:
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