Mechanisms of cell competition: themes and variations.

Mechanisms of cell competition: themes and variations.
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细胞竞争的机制:主题和变化。

DOI:
10.1083/jcb.201301051
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发表时间:
2013-03-18
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Moreno E
Moreno E
中科院分区:
其他
文献类型:
--
作者:
Levayer R;Moreno E

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细胞竞争是当面对快速增长的群体时,通过凋亡短距离消除缓慢分裂的细胞。它是基于相邻细胞之间的相对细胞适应性的比较,是组织适应性的一个引人注目的例子,可能在果蝇和哺乳动物的发育错误纠正和癌症进展中发挥核心作用。细胞竞争导致发现了影响细胞适应性和驱动细胞消除的多种途径。这些途径的多样性可能反映了不相关的现象,但最近的证据表明,一些共同的布线和存在一个真正的健身比较途径。
Cell competition is the short-range elimination of slow-dividing cells through apoptosis when confronted with a faster growing population. It is based on the comparison of relative cell fitness between neighboring cells and is a striking example of tissue adaptability that could play a central role in developmental error correction and cancer progression in both Drosophila melanogaster and mammals. Cell competition has led to the discovery of multiple pathways that affect cell fitness and drive cell elimination. The diversity of these pathways could reflect unrelated phenomena, yet recent evidence suggests some common wiring and the existence of a bona fide fitness comparison pathway.
DOI: 10.1073/pnas.1113882109
发表时间: 2012-01-10
影响因子: 11.1
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