Concise Review: Wharton's Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells.
Concise Review: Wharton's Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells.
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DOI：
10.1002/sctm.16-0492
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发表时间：
2017-07
影响因子：
6
通讯作者：
Keating A
中科院分区：
文献类型：
--
作者：
Davies JE;Walker JT;Keating A
脐带已成为越来越多的间充质基质细胞来源，用于临床前研究和最近的临床研究。尽管活性有所增加，但这一细胞群体的几个方面一直被低估。关键问题是对脊髓内的解剖结构缺乏共识，潜在的不同人群被确定为起源于单一来源。为了帮助解决这些问题，我们提出了一个基于组织学的脐带结构命名法，并对其发育起源和成分进行了分析。讨论了从华顿果冻中分离细胞的方法，并对细胞的免疫表型和克隆特性进行了评价。此外，还讨论了细胞的血管周围起源。最后，简要回顾了脐带细胞的临床试验。由于许多原因，对来自不同组织来源的间充质基质细胞进行的许多临床研究的结果的解释是具有挑战性的。因此，尤其重要的是，随着脐带细胞越来越多地应用于治疗，我们努力更好地了解来自这一重要组织来源的细胞的来源和功能特征。干细胞转化医学2017；6：1620-1630
The umbilical cord has become an increasingly used source of mesenchymal stromal cells for preclinical and, more recently, clinical studies. Despite the increased activity, several aspects of this cell population have been under‐appreciated. Key issues are that consensus on the anatomical structures within the cord is lacking, and potentially different populations are identified as arising from a single source. To help address these points, we propose a histologically based nomenclature for cord structures and provide an analysis of their developmental origins and composition. Methods of cell isolation from Wharton's jelly are discussed and the immunophenotypic and clonal characteristics of the cells are evaluated. The perivascular origin of the cells is also addressed. Finally, clinical trials with umbilical cord cells are briefly reviewed. Interpreting the outcomes of the many clinical studies that have been undertaken with mesenchymal stromal cells from different tissue sources has been challenging, for many reasons. It is, therefore, particularly important that as umbilical cord cells are increasingly deployed therapeutically, we strive to better understand the derivation and functional characteristics of the cells from this important tissue source. Stem Cells Translational Medicine 2017;6:1620–1630
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影响因子：
3.3
作者：
Ding, Dah-Ching;Chang, Yu-Hsun;Lin, Shinn-Zong
通讯作者：
Lin, Shinn-Zong
影响因子：
3.8
作者：
Coskun, H.;Can, A.
通讯作者：
Can, A.
影响因子：
5.3
作者：
Carreau A;El Hafny-Rahbi B;Matejuk A;Grillon C;Kieda C
通讯作者：
Kieda C
DOI：
10.3109/14767058.2015.1076387
发表时间：
2016-01-01
影响因子：
1.8
作者：
Candilera, Vanessa;Bouche, Carlo;Pederiva, Federica
通讯作者：
Pederiva, Federica
影响因子：
1.5
作者：
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通讯作者：
Kawiak, Jerzy