Vitamin D and bronchopulmonary dysplasia in preterm infants.
Vitamin D and bronchopulmonary dysplasia in preterm infants.
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DOI：
10.1038/jp.2016.115
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发表时间：
2016-10
影响因子：
2.9
通讯作者：
Christou, H.
中科院分区：
文献类型：
--
作者：
Joung, K. E.;Burris, H. H.;Van Marter, L. J.;McElrath, T. F.;Michael, Z.;Tabatabai, P.;Litonjua, A. A.;Weiss, S. T.;Christou, H.
维生素D缺乏与儿童期哮喘和反应性气道疾病有关，但其对早产儿支气管肺发育不良（BPD）的潜在影响尚不清楚。早产儿出生时25-羟基维生素D（25（OH）D）水平较低，出生后有营养缺乏的风险。本研究的目的是评估29周前出生的早产儿出生时和36周校正胎龄时25（OH）D浓度与BPD的关系。我们收集了44名在波士顿布里格姆妇女医院分娩的早产儿（胎龄<29周）的脐带血样本。此外，在父母同意下，我们从20名在妊娠29周前出生的早产儿（包括6名先前采集脐带血的婴儿）中采集了36周校正年龄的静脉样本。将样品在-80 °C下冷冻，直到随后通过化学发光测量25（OH）D水平。我们使用多变量logistic模型调整胎龄，并考虑其他混杂变量，包括母亲种族、年龄、分娩方式和婴儿性别。44例婴儿中，41例（93.2%）存活，3例（6.8%）在36周龄前死亡。出生时25（OH）D水平的中位数在随后死亡或发展为BPD的早产儿中为30.4 ng ml−1，在没有BPD的存活婴儿中为33.8 ng ml−1（P=0.6）。在校正年龄36周时，无BPD存活者的25（OH）D水平中位数为59.0 ng ml-1，BPD存活者为64.2 ng ml-1（P=0.9）。脐带血和36周校正的25（OH）D水平均与死亡或BPD的几率无关（校正的比值比（OR）1.00，95%置信区间（CI）：0.73 - 1.37; OR 0.93，95% CI：0.61 - 1.43）。在这群极早产儿中，脐带血和36周校正年龄的25（OH）D水平均与BPD的发生无关。值得注意的是，在目前的补充水平下，我们队列中的所有极早产儿在36周校正年龄时都达到了25（OH）D水平>30 ng ml−1，这被认为代表了成人和儿科人群的充足性。
Vitamin D deficiency is associated with asthma and reactive airway disease in childhood but its potential contribution to bronchopulmonary dysplasia (BPD) in preterm infants is unknown. Preterm infants have lower levels of 25-hydroxyvitamin D (25(OH)D) at birth and are at risk for nutritional deficiencies after birth. The objective of the study was to evaluate the association of 25(OH)D concentrations at birth and at 36 weeks' corrected gestational age with BPD in preterm infants born before 29 completed weeks of gestation. We collected umbilical cord blood samples from 44 preterm infants (gestational age <29 weeks) delivered at Brigham and Women's Hospital in Boston. In addition, with parental consent we collected venous samples at 36 weeks' corrected age from 20 preterm infants born before 29 weeks' gestation (including 6 infants with previously collected cord blood). Samples were frozen at −80 °C until subsequent measurement of 25(OH)D levels by chemiluminescence. We used multivariable logistic models to adjust for gestational age and considered other confounding variables, including maternal race, age, mode of delivery and infant sex. Among 44 infants, 41 (93.2%) survived and 3 (6.8%) died before 36 weeks' corrected age. Median 25(OH)D levels at birth were 30.4 ng ml−1 in preterm infants who subsequently died or developed BPD and 33.8 ng ml−1 in infants who survived without BPD (P=0.6). Median 25(OH)D levels at corrected age of 36 weeks were 59.0 ng ml−1 among survivors without BPD and 64.2 ng ml−1 among survivors with BPD (P=0.9). Neither cord blood nor 36 weeks' corrected 25(OH)D levels were associated with odds of death or BPD (adjusted odds ratio (OR) 1.00, 95% confidence interval (CI): 0.73 to 1.37; and OR 0.93, 95% CI: 0.61 to 1.43, respectively). Among this population of extremely preterm infants neither cord blood nor the 36 weeks' corrected age 25(OH)D levels were associated with development of BPD. Notably, at the current level of supplementation, all extremely preterm infants in our cohort had achieved 25(OH)D levels >30 ng ml−1 by 36 weeks' corrected age, which is thought to represent sufficiency in adult and pediatric populations.
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影响因子：
5.9
作者：
Navas-Nazario, Aledie;Li, Fang Yong;Shabanova, Veronika;Weiss, Pnina;Cole, David E. C.;Carpenter, Thomas O.;Bazzy-Asaad, Alia
通讯作者：
Bazzy-Asaad, Alia
影响因子：
3.6
作者：
Burris, Heather H.;Van Marter, Linda J.;McElrath, Thomas F.;Tabatabai, Patrik;Litonjua, Augusto A.;Weiss, Scott T.;Christou, Helen
通讯作者：
Christou, Helen
影响因子：
2.8
作者：
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通讯作者：
MacFarlane, GD
DOI：
10.1024/0300-9831/a000165
发表时间：
2013-08-01
影响因子：
2.3
作者：
Ataseven, Fevzi;Aygun, Canan;Kucukoduk, Sukru
通讯作者：
Kucukoduk, Sukru
DOI：
10.1152/ajplung.00344.2013
发表时间：
2014-03-01
影响因子：
4.9
作者：
Mandell, Erica;Seedorf, Gregory;Abman, Steven H.
通讯作者：
Abman, Steven H.