Vitamin D status among preterm and full-term infants at birth.
Vitamin D status among preterm and full-term infants at birth.
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DOI：
10.1038/pr.2013.174
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发表时间：
2014-01
影响因子：
3.6
通讯作者：
Christou, Helen
中科院分区：
文献类型：
--
作者：
Burris, Heather H.;Van Marter, Linda J.;McElrath, Thomas F.;Tabatabai, Patrik;Litonjua, Augusto A.;Weiss, Scott T.;Christou, Helen
母亲维生素D缺乏和早产的危险因素重叠，但早产儿中25-羟基维生素D（25（OH）D）水平的分布尚不清楚。我们的目的是确定25（OH）D水平和胎龄之间的关系。我们测量了471名在波士顿布里格姆妇女医院出生的婴儿的脐带血浆25（OH）D水平。我们使用广义估计方程来确定早产儿（<37孕周）或极早产儿（<32孕周）的25（OH）D水平< 20 ng/ml的几率是否高于更成熟的婴儿。我们调整了出生季节、母亲年龄、种族、婚姻状况和单胎或多胎妊娠的潜在混杂因素。平均脐带血浆25（OH）D水平为34.0 ng/ml（范围4.1至95.3，SD 14.1）。与更成熟的婴儿相比，妊娠32周前出生的婴儿在未校正的模型（OR 2.2，95%CI 1.1，4.3）和校正的模型（OR 2.4，95%CI 1.2，5.3）中25（OH）D水平< 20 ng/ml的几率增加。小于32周出生的婴儿比更成熟的婴儿有更高的风险，因为25（OH）D水平低。因此，需要进一步研究低25（OH）D水平与早产及其后遗症之间的关系。
Risk factors for maternal vitamin D deficiency and preterm birth overlap but the distribution of 25-hydroxyvitamin D (25(OH)D) levels among preterm infants is not known. We aimed to determine associations between 25(OH)D levels and gestational age. We measured umbilical cord plasma levels of 25(OH)D from 471 infants born at Brigham and Women’s Hospital in Boston. We used generalized estimating equations to determine whether preterm (<37 weeks’ gestation) or very preterm (<32 weeks’ gestation) infants had greater odds of 25(OH)D levels < 20 ng/ml than more mature infants. We adjusted for potential confounding by season of birth, maternal age, race, marital status and singleton or multiple gestation. Mean cord plasma 25(OH)D level was 34.0 ng/ml (range 4.1 to 95.3, and SD 14.1). Infants born before 32 weeks’ gestation had increased odds of 25(OH)D levels < 20 ng/ml in unadjusted (OR 2.2, 95% CI 1.1, 4.3) and adjusted models (OR 2.4, 95% CI 1.2, 5.3) compared to more mature infants. Infants born < 32 weeks’ gestation are at higher risk than more mature infants for low 25(OH)D levels. Further investigation of the relationships between low 25(OH)D levels and preterm birth and its sequelae is thus warranted.
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影响因子：
4.2
作者：
Bodnar, Lisa M.;Catov, Janet M.;Simhan, Hyagriv N.
通讯作者：
Simhan, Hyagriv N.
影响因子：
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Ersfeld, DL;Rao, DS;MacFarlane, GD
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MacFarlane, GD
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Amukele, Timothy K.;Soko, Dean;Taha, Taha E.
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Taha, Taha E.
影响因子：
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作者：
Bodnar, Lisa M.;Catov, Janet M.;Simhan, Hyagriv N.
通讯作者：
Simhan, Hyagriv N.
影响因子：
158.5
作者：
David, RJ;Collins, JW
通讯作者：
Collins, JW