Critical periods when dopamine controls behavioral responding during Pavlovian learning.
Critical periods when dopamine controls behavioral responding during Pavlovian learning.
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DOI：
10.1007/s00213-022-06182-w
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发表时间：
2022-09
影响因子：
3.4
通讯作者：
Wanat, Matthew J.
中科院分区：
文献类型：
--
作者：
Lefner, Merridee J.;Stelly, Claire E.;Fonzi, Kaitlyn M.;Zurita, Hector;Wanat, Matthew J.
了解奖励和预测性线索之间的联系对于食欲行为反应至关重要。中脑边缘多巴胺系统被认为在建立这些线索-奖赏联系中起着不可或缺的作用。多巴胺对线索的反应可以发出奖赏价值不同的信号，尽管这种差异只有在经过大量训练后才会出现。这表明，多巴胺系统可能会根据训练阶段的不同而不同地调节行为反应。这项研究的目的是确定拮抗多巴胺受体是否对行为产生不同的影响，这取决于训练的阶段或巴甫洛夫任务的类型。不同组的雄性大鼠接受了巴甫洛夫任务的训练，在这些任务中，不同的音频提示要么表示奖励大小的不同，要么表示奖励比率的差异。在前十次训练(获得阶段)或后十次训练(表达阶段)之前，系统地给予多巴胺受体拮抗剂氟苯硫醇，我们在另外十次训练中监测了这些操作的效果。在这两个巴甫洛夫任务中，我们发现了多巴胺受体拮抗剂对条件性反应、反应潜伏期和奖赏后头部条目的急性影响。有趣的是，在表达阶段的多巴胺受体拮抗只在接受奖励大小巴甫洛夫任务训练的大鼠中产生了持续性的行为反应缺陷。总之，我们的结果表明，多巴胺在巴甫洛夫任务中对行为的控制取决于一个人之前的训练经验和线索发出的信息。
Learning the association between rewards and predictive cues is critical for appetitive behavioral responding. The mesolimbic dopamine system is thought to play an integral role in establishing these cue-reward associations. The dopamine response to cues can signal differences in reward value, though this emerges only after significant training. This suggests that the dopamine system may differentially regulate behavioral responding depending on the phase of training. The purpose of this study was to determine whether antagonizing dopamine receptors elicited different effects on behavior depending on the phase of training or the type of Pavlovian task. Separate groups of male rats were trained on Pavlovian tasks in which distinct audio cues signaled either differences in reward size or differences in reward rate. The dopamine receptor antagonist flupenthixol was systemically administered prior to either the first ten sessions of training (acquisition phase) or the second ten sessions of training (expression phase) and we monitored the effect of these manipulations for an additional ten training sessions. We identified acute effects of dopamine receptor antagonism on conditioned responding, the latency to respond, and post-reward head entries in both Pavlovian tasks. Interestingly, dopamine receptor antagonism during the expression phase produced persistent deficits in behavioral responding only in rats trained on the reward size Pavlovian task. Together, our results illustrate that dopamine’s control over behavior in Pavlovian tasks depends upon one’s prior training experience and the information signaled by the cues.
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影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
5.4
作者：
Horvitz, JC
通讯作者：
Horvitz, JC
影响因子：
25
作者：
Lee, Kwang;Claar, Leslie D.;Masmanidis, Sotiris C.
通讯作者：
Masmanidis, Sotiris C.
中断多巴胺对未来奖励编码的可取消成本和利益编码。
影响因子：
25
作者：
Gan JO;Walton ME;Phillips PE
通讯作者：
Phillips PE
影响因子：
5.3
作者：
Di Ciano, P;Cardinal, RN;Everitt, BJ
通讯作者：
Everitt, BJ