Circadian clocks regulate cardiac arrhythmia susceptibility, repolarization, and ion channels.
Circadian clocks regulate cardiac arrhythmia susceptibility, repolarization, and ion channels.
复制标题
DOI：
10.1016/j.coph.2020.09.015
复制
发表时间：
2021-04
影响因子：
4
通讯作者：
Schroder EA
中科院分区：
文献类型：
--
作者：
Delisle BP;Stumpf JL;Wayland JL;Johnson SR;Ono M;Hall D;Burgess DE;Schroder EA
心脏性猝死（SCD）发病率的每日变化揭示了环境节律和内部昼夜节律之间的相互作用。昼夜节律是改变生理以预测环境中的每日变化的生理节律。它们反映了存在于全身的细胞生物钟的协调活动。这篇综述通过总结几种不同的转基因小鼠模型的结果来概述该领域的现状，这些转基因小鼠模型破坏了整个身体、心肌细胞或成年心肌细胞的生物钟功能。这些研究确定了生物钟在调节心率、心室复极、心肌发生和心脏离子通道功能表达中的重要作用。它们突出了心脏兴奋性调节的新维度，并代表了对时间如何影响离子通道、心脏兴奋性和SCD发病率的一天中的时间变化的功能调节的复杂性的初步探索。该图形象征了众所周知的观察结果，即心脏电生理学在一天中的不同时间发生变化。临床上，心脏性猝死显示出某些类型心脏病的发病率在一天中的某个时间增加。为了更好地了解环境和基因相互作用如何影响心脏电生理学，一些研究人员已经建立了转基因小鼠模型，这些模型破坏了包括心脏在内的不同组织中的生物钟。这些研究显示了功能性生物钟在调节心率、扩张型心肌病的发展、心脏复极和心脏离子通道中的作用。
Daily changes in the incidence of sudden cardiac death (SCD) reveal an interaction between environmental rhythms and internal circadian rhythms. Circadian rhythms are physiological rhythms that alter physiology to anticipate daily changes in the environment. They reflect coordinated activity of cellular circadian clocks that exist throughout the body. This review provides an overview of the state of the field by summarizing the results of several different transgenic mouse models that disrupt the function of circadian clocks throughout the body, in cardiomyocytes, or in adult cardiomyocytes. These studies identify important roles for circadian clocks in regulating heart rate, ventricular repolarization, arrhythmogenesis, and the functional expression of cardiac ion channels. They highlight a new dimension in the regulation of cardiac excitability and represent initial forays into understanding the complexities of how time impacts the functional regulation of ion channels, cardiac excitability, and time of day changes in the incidence of SCD. The graphic symbolizes the well-known observation that cardiac electrophysiology changes at different times of day. Clinically, sudden cardiac death is shown to have a time of day increase incidence for certain types of heart disease. To better understand how environment and gene interactions contribute to cardiac electrophysiology, several investigators have generated transgenic mouse models that disrupt circadian clocks in different tissues including the heart. These studies show a role for functional circadian clocks in regulating heart rate, the development of dilated cardiomyopathy, cardiac repolarization, and cardiac ion channels.
登录
查看更多内容
影响因子：
64.5
作者：
Balsalobre, A;Damiola, F;Schibler, U
通讯作者：
Schibler, U
影响因子：
2.8
作者：
GOLDBERG, RJ;BRADY, P;DALEN, JE
通讯作者：
DALEN, JE
影响因子：
3.5
作者：
Hughes ME;Hogenesch JB;Kornacker K
通讯作者：
Kornacker K
影响因子：
20.1
作者：
Dobrev D;Wehrens XHT
通讯作者：
Wehrens XHT
影响因子：
56.9
作者：
Darlington, TK;Wager-Smith, K;Kay, SA
通讯作者：
Kay, SA