Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography.
Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography.
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DOI：
10.1016/j.brainres.2009.04.025
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发表时间：
2009-06-18
期刊：
影响因子：
2.9
通讯作者：
Ewing-Cobbs L
中科院分区：
文献类型：
--
作者：
Hasan KM;Iftikhar A;Kamali A;Kramer LA;Ashtari M;Cirino PT;Papanicolaou AC;Fletcher JM;Ewing-Cobbs L
人脑钩束（UF）是一个重要的皮质-皮质白色物质通路，直接连接额叶和颞叶，但缺乏确切的功能支持。使用弥散张量纤维束成像，我们提取UF，计算其体积，并将其相对于每个受试者的颅内体积（ICV）进行标准化，并分析其相应的DTI指标双边对108个右利手的儿童和成人年龄在7-68岁的队列。结果显示，分数各向异性（FA）的倒U形曲线随着年龄的增长和U形曲线的径向和轴向扩散率反映白色物质的进步和倒退髓鞘和连贯性的动态，继续到年轻的成年。儿童（p=0.05）、成人（p =0.0012）和整个样本（p =0.0002）左侧UF的平均FA值显著更大。FA扩散不对称性（左>右）是由于轴向扩散率的扩散不对称性增加（p<0.0001）和径向扩散率缺乏不对称性（p>0.23）。这是第一项研究，以提供基线规范的宏观和微观结构的年龄轨迹的人类UF整个生命周期。这项研究的结果可能有助于更好地了解UF在未来的行为和临床研究中的作用。
The human brain uncinate fasciculus (UF) is an important cortico-cortical white matter pathway that directly connects the frontal and temporal lobes, although there is a lack of conclusive support for its exact functional role. Using diffusion tensor tractography, we extracted the UF, calculated its volume and normalized it with respect to each subject’s intracranial volume (ICV) and analyzed its corresponding DTI metrics bilaterally on a cohort of 108 right-handed children and adults aged 7–68 years. Results showed inverted U-shaped curves for fractional anisotropy (FA) with advancing age and U-shaped curves for radial and axial diffusivities reflecting white matter progressive and regressive myelination and coherence dynamics that continue into young adulthood. The mean FA values of the UF were significantly larger on the left side in children (p=0.05), adults (p=0.0012) and the entire sample (p=0.0002). The FA leftward asymmetry (Left > Right) is shown to be due to increased leftward asymmetry in the axial diffusivity (p<0.0001) and a lack of asymmetry (p>0.23) for the radial diffusivity. This is the first study to provide baseline normative macro and microstructural age trajectories of the human UF across the lifespan. Results of this study may lend themselves to better understanding of UF role in future behavioral and clinical studies.
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