Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9.
Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9.
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DOI：
10.1517/13543784.2012.681043
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发表时间：
2012-06
影响因子：
6.1
通讯作者：
Santos JM
中科院分区：
文献类型：
--
作者：
Kowluru RA;Zhong Q;Santos JM
糖尿病视网膜病变仍然是最令人担心的糖尿病并发症之一。尽管该领域进行了广泛的研究，但导致这种缓慢进展疾病发展的分子机制仍不清楚。在糖尿病视网膜病变的发病机制中，在观察到与该疾病相关的组织病理学之前，线粒体受损并且炎症介质升高。基质金属蛋白酶 (MMP) 调节多种细胞功能，包括细胞凋亡和血管生成。糖尿病环境会刺激多种 MMP 的分泌，这些 MMP 被认为参与并发症，包括视网膜病变、肾病和心肌病。糖尿病视网膜病变患者和动物模型的视网膜和玻璃体中 MMP-9 和 MMP-2 含量增加。最近的研究表明，MMP 在糖尿病视网膜病变的发展中具有双重作用；在疾病的早期阶段（新生血管形成前），MMP-2 和 MMP-9 可能通过损害线粒体来促进视网膜毛细血管细胞的凋亡，而在后期阶段，它们有助于新生血管形成。本文回顾了文献，评估了 MMP（尤其是 MMP-9）在糖尿病视网膜病变发展中的作用，并提出了现有证据，表明针对 MMP-9 的抑制剂（取决于给药时糖尿病的持续时间）有可能预防这种致盲疾病的进展，并保护视力丧失。 MMP抑制剂可能具有双重作用：在疾病的早期阶段，抑制毛细血管细胞凋亡；如果疾病已进展到血管生成阶段，则抑制新血管的生长。
Diabetic retinopathy remains one of the most feared complications of diabetes. Despite extensive research in the field, the molecular mechanism responsible for the development of this slow progressing disease remains unclear. In the pathogenesis of diabetic retinopathy, mitochondria are damaged and inflammatory mediators are elevated before the histopathology associated with the disease can be observed. Matrix metalloproteinases (MMPs) regulate a variety of cellular functions including apoptosis and angiogenesis. Diabetic environment stimulates the secretion of several MMPs that are considered to participate in complications, including retinopathy, nephropathy and cardiomyopathy. Patients with diabetic retinopathy and also animal models have shown increased MMP-9 and MMP-2 in their retina and vitreous. Recent research has shown that MMPs have dual role in the development of diabetic retinopathy; in the early stages of the disease (pre-neovascularization), MMP-2 and MMP-9 facilitate the apoptosis of retinal capillary cells, possibly via damaging the mitochondria, and in the later phase, they help in neovascularization. This article reviews the literature to evaluate the role of MMPs, especially MMP-9, in the development of diabetic retinopathy, and presents existing evidence that the inhibitors targeted toward MMP-9, depending on the duration of diabetes at the times their administration could have potential to prevent the progression of this blinding disease, and protect the vision loss. Inhibitors of MMPs could have dual role: in the early stages of the diseases, inhibit capillary cell apoptosis, and if the disease has progressed to the angiogenic stage, inhibit the growth of new vessels.
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影响因子：
6.4
作者：
Chetty, Chandramu;Lakka, Sajani S.;Bhoopathi, Praveen;Rao, Jasti S.
通讯作者：
Rao, Jasti S.
影响因子：
3
作者：
Chan PS;Kanwar M;Kowluru RA
通讯作者：
Kowluru RA
影响因子：
15.9
作者：
Barber, AJ;Lieth, E;Gardner, TW
通讯作者：
Gardner, TW
DOI：
10.1023/b:jobb.0000041755.22613.8d
发表时间：
2004-08-01
影响因子：
3
作者：
Dawson, VL;Dawson, TM
通讯作者：
Dawson, TM
影响因子：
2.1
作者：
Aiello, LP
通讯作者：
Aiello, LP