Effects of Deep Brain Stimulation on Eye Movements and Vestibular Function.
Effects of Deep Brain Stimulation on Eye Movements and Vestibular Function.
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DOI：
10.3389/fneur.2018.00444
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发表时间：
2018
影响因子：
3.4
通讯作者：
Ghasia FF
中科院分区：
文献类型：
--
作者：
Shaikh AG;Antoniades C;Fitzgerald J;Ghasia FF
基底神经节互锁电路的发现和脑深部电刺激（DBS）调制的发明是基础和临床神经科学的突破。DBS不仅改变了数十万患有顽固性运动障碍的人的生活质量，而且还提供了一个独特的机会来了解基底神经节如何与其他神经结构相互作用。DBS对眼球运动和前庭功能的研究是一个有吸引力但较少探索的领域。从临床角度来看，这些研究为刺激曲线的有效编程提供了有价值的指导，从而获得最佳的运动结果。从科学的角度来看，这些研究提供了评估基底神经节刺激对认知和运动领域中的眼球运动行为的结果的能力。理解DBS对眼运动功能的影响也导致类比来解释其对复杂的眼轴和轴向运动功能的影响。本文就苍白球、丘脑底核和丘脑DBS对眼运动和前庭功能的影响作一综述。基底神经节的解剖和生理，DBS和眼球运动的原则有关，进行了讨论。解释电刺激基底神经节对帕金森病的影响需要了解患病大脑中的基线眼运动功能。因此，我们还讨论了这些患者的基线眼运动缺陷以及DBS如何改变这些功能。
Discovery of inter-latching circuits in the basal ganglia and invention of deep brain stimulation (DBS) for their modulation is a breakthrough in basic and clinical neuroscience. The DBS not only changes the quality of life of hundreds of thousands of people with intractable movement disorders, but it also offers a unique opportunity to understand how the basal ganglia interacts with other neural structures. An attractive yet less explored area is the study of DBS on eye movements and vestibular function. From the clinical perspective such studies provide valuable guidance in efficient programming of stimulation profile leading to optimal motor outcome. From the scientific standpoint such studies offer the ability to assess the outcomes of basal ganglia stimulation on eye movement behavior in cognitive as well as in motor domains. Understanding the influence of DBS on ocular motor function also leads to analogies to interpret its effects on complex appendicular and axial motor function. This review focuses on the influence of globus pallidus, subthalamic nucleus, and thalamus DBS on ocular motor and vestibular functions. The anatomy and physiology of basal ganglia, pertinent to the principles of DBS and ocular motility, is discussed. Interpretation of the effects of electrical stimulation of the basal ganglia in Parkinson's disease requires understanding of baseline ocular motor function in the diseased brain. Therefore we have also discussed the baseline ocular motor deficits in these patients and how the DBS changes such functions.
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
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通讯作者：
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