Metabolic Features of Tumor Dormancy: Possible Therapeutic Strategies.
Metabolic Features of Tumor Dormancy: Possible Therapeutic Strategies.
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DOI：
10.3390/cancers14030547
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发表时间：
2022-01-21
期刊：
影响因子：
5.2
通讯作者：
Taddei ML
中科院分区：
文献类型：
--
作者：
Pranzini E;Raugei G;Taddei ML
肿瘤复发仍然是癌症患者面临的主要临床挑战。癌细胞在重新出现之前可能会经历很长一段时间的休眠状态。细胞内和细胞外驱动的通路都参与维持休眠状态和随后的觉醒，其机制大多尚不清楚。在这种情况下，癌症代谢正在成为肿瘤进展和扩散的关键驱动因素，并在癌症研究中得到越来越多的关注。这篇综述主要集中在代谢适应的特点，休眠表型和支持肿瘤的再生长。破译维持肿瘤休眠的代谢适应可能为基于联合代谢药物预防肿瘤复发的新的治疗方法铺平道路。肿瘤复发是癌症治疗的主要障碍之一。许多患者经历了癌症复发，甚至在最初的肿瘤根除后几十年，发展成更具侵袭性和转移性的疾病。这种现象与休眠癌细胞的出现有关，其特征是细胞周期停滞，对传统抗癌疗法基本不敏感。这些稀有和难以捉摸的细胞可能在细胞内外因素的诱导下重新获得增殖能力，从而促进肿瘤的重新生长和转移形成。耐药休眠细胞维持和苏醒的分子机制很有趣，但目前仍在很大程度上不得而知。然而，最近越来越多的证据表明，细胞周期进程强烈依赖于癌细胞的代谢适应。即使休眠细胞经常表现为代谢减慢和应对氧化应激的能力增强，但不同的因素，如细胞外基质组成、基质细胞的影响和营养的可获得性，可能会决定休眠细胞的特定变化，最终导致肿瘤复发。这篇综述的主要主题是破译参与肿瘤细胞休眠的代谢途径的作用，为选择性地针对这些细胞提供新的策略，以防止致命的复发和最大限度地发挥治疗效果。
Tumor recurrence still represents a major clinical challenge for cancer patients. Cancer cells may undergo a dormant state for long times before re-emerging. Both intracellular- and extracellular-driven pathways are involved in maintaining the dormant state and the subsequent awakening, with a mechanism that is still mostly unknown. In this scenario, cancer metabolism is emerging as a critical driver of tumor progression and dissemination and have gained increasing attention in cancer research. This review focuses on the metabolic adaptations characterizing the dormant phenotype and supporting tumor re-growth. Deciphering the metabolic adaptation sustaining tumor dormancy may pave the way for novel therapeutic approaches to prevent tumor recurrence based on combined metabolic drugs. Tumor relapse represents one of the main obstacles to cancer treatment. Many patients experience cancer relapse even decades from the primary tumor eradication, developing more aggressive and metastatic disease. This phenomenon is associated with the emergence of dormant cancer cells, characterized by cell cycle arrest and largely insensitive to conventional anti-cancer therapies. These rare and elusive cells may regain proliferative abilities upon the induction of cell-intrinsic and extrinsic factors, thus fueling tumor re-growth and metastasis formation. The molecular mechanisms underlying the maintenance of resistant dormant cells and their awakening are intriguing but, currently, still largely unknown. However, increasing evidence recently underlined a strong dependency of cell cycle progression to metabolic adaptations of cancer cells. Even if dormant cells are frequently characterized by a general metabolic slowdown and an increased ability to cope with oxidative stress, different factors, such as extracellular matrix composition, stromal cells influence, and nutrient availability, may dictate specific changes in dormant cells, finally resulting in tumor relapse. The main topic of this review is deciphering the role of the metabolic pathways involved in tumor cells dormancy to provide new strategies for selectively targeting these cells to prevent fatal recurrence and maximize therapeutic benefit.
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影响因子：
11.2
作者：
Barkan D;Kleinman H;Simmons JL;Asmussen H;Kamaraju AK;Hoenorhoff MJ;Liu ZY;Costes SV;Cho EH;Lockett S;Khanna C;Chambers AF;Green JE
通讯作者：
Green JE
DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
DOI：
10.1007/978-3-030-65768-0_1
发表时间：
2021-01-01
期刊：
HETEROGENEITY OF CANCER METABOLISM, 2ND EDITION
影响因子：
--
作者：
Bose, Sminu;Zhang, Cissy;Le, Anne
通讯作者：
Le, Anne
影响因子：
64.8
作者：
通讯作者：
--
自噬和癌症休眠。
影响因子：
4.7
作者：
Akkoc Y;Peker N;Akcay A;Gozuacik D
通讯作者：
Gozuacik D