Long-term follow-up of hexamethylene diisocyanate-, diphenylmethane diisocyanate-, and toluene diisocyanate-induced asthma.
Long-term follow-up of hexamethylene diisocyanate-, diphenylmethane diisocyanate-, and toluene diisocyanate-induced asthma.
复制标题
对六亚甲基二异氰酸酯、二苯基甲烷二异氰酸酯和甲苯二异氰酸酯诱发的哮喘进行长期随访。
DOI：
--
复制
发表时间：
2000
影响因子：
24.7
通讯作者：
M. Tuppurainen
中科院分区：
文献类型：
--
作者：
P. Piirilä;Henrik Nordman;HELENA M. Keskinen;R. Luukkonen;S. Salo;Timo Tuomi;M. Tuppurainen
1976年至1992年，新诊断出245例由二异氰酸酯引起的哮喘病例，其中39%由六亚甲基二异氰酸酯(HDI)引起，39%由二苯甲烷二异氰酸酯(MDI)引起，17%由甲苯二异氰酸酯(TDI)引起。我们的目的是研究二异氰酸酯诱发的哮喘的临床结果。 1995年向235名活着的患者发出了一份调查问卷，并通过对其中91名患者进行临床复查进行了验证。该研究平均在诊断后 10 年进行。 82% 的患者出现哮喘症状，34% 的患者未服用药物，35% 的患者定期服用药物。与 IgE 阴性患者相比，显示异氰酸酯免疫球蛋白 E (IgE) 抗体的患者使用的药物较少（OR 0.273；CI 0.098，0.758），并且哮喘症状较少（OR 0.329；CI 0.124，0.875）。与 IgE 阴性患者相比，他们的症状持续时间 (p = 0.0025)、潜伏期 (p = 0.0249) 和暴露持续时间 (p = 0.0008) 也显着缩短。然而，这并不能完全解释 IgE 阳性患者的更有利结果。 HDI 诱发的哮喘患者比 MDI 和 TDI 诱发的哮喘患者使用更少的药物（OR 0.412；CI 0.229，0.739）。结果证实二异氰酸酯诱发的哮喘的医疗结果通常相当差；在 TDI 诱发的哮喘中，症状持续存在和非特异性支气管反应非常明显。更有利的结果与 IgE 介导和 HDI 诱导相关。
In 1976-1992 245 new cases of asthma induced by diisocyanates were diagnosed, caused by hexamethylene diisocyanate (HDI) in 39%, diphenylmethane diisocyanate (MDI) in 39%, and toluene diisocyanate (TDI) in 17% of the cases. Our aim was to study the clinical outcome of diisocyanate-induced asthma. A questionnaire was sent to the 235 patients alive in 1995, and validated by reexamining clinically 91 of them. The study was carried out on average 10 () yr after the diagnosis. Of the patients 82% experienced symptoms of asthma, 34% used no medication, and 35% were on regular medication. The patients having displayed immunoglobulin E (IgE) antibodies to isocyanates used less medication (OR 0.273; CI 0.098, 0.758) and had fewer symptoms of asthma (OR 0.329; CI 0.124, 0.875) than the IgE-negative ones. They also had a significantly shorter duration of symptoms (p = 0.0025), latency period (p = 0.0249), and duration of exposure (p = 0.0008) than the IgE-negative patients. This did not, however, entirely explain the more favourable outcome of the IgE-positive patients. Patients with HDI-induced asthma used less medication (OR 0.412; CI 0.229, 0.739) than patients with MDI- and TDI-induced asthma. The results confirm the generally rather poor medical outcome of diisocyanate-induced asthma; the persistence of symptoms and unspecific bronchial reactivity were pronounced in TDI-induced asthma. A more favourable outcome was associated with IgE mediation and HDI inducement.
对产业工人甲苯二异氰酸酯抗体的调查。
DOI：
10.1097/00043764-198111000-00007
发表时间：
1981
期刊：
Journal of occupational medicine. : official publication of the Industrial Medical Association
影响因子：
--
作者：
Karol,MH
通讯作者：
Karol,MH
对新甲苯二异氰酸酯制造厂雇用的工人进行的五年纵向研究。
DOI：
10.1164/arrd.1982.126.3.420
发表时间：
1982
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Diem,JE;Jones,RN;Hendrick,DJ;Glindmeyer,HW;Dharmarajan,V;Butcher,BT;Salvaggio,JE;Weill,H
通讯作者：
Weill,H