Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma.
Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma.
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DOI：
10.18632/oncotarget.21733
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发表时间：
2017-11-28
期刊：
影响因子：
--
通讯作者：
Medeiros R
中科院分区：
文献类型：
--
作者：
Dias F;Teixeira AL;Ferreira M;Adem B;Bastos N;Vieira J;Fernandes M;Sequeira MI;Maurício J;Lobo F;Morais A;Oliveira J;Kok K;Medeiros R
肾细胞癌（RCC）对临床医生来说是一个挑战，因为筛查和监测测试的不存在导致三分之一的患者被诊断患有转移性疾病，其余患者中的20-40%也会发生转移。现代医学正试图建立循环生物分子作为生物标志物的黄金标准。在可以从肿瘤细胞释放的分子中，我们可以找到microRNA。本研究的目的是评估癌症相关的miR-210、miR-218、miR-221和miR-1233作为RCC预后生物标志物的适用性。miR-210、miR-221和miR-1233水平较高的患者出现RCC特异性死亡的风险较高，癌症特异性生存率较低。与临床医生目前使用的变量相比，增加miR-210、miR-221和miR-1233血浆水平信息提高了8.4%的癌症死亡预测能力。我们还证实了缺氧刺激miR-210和miR-1233从HKC-8、RCC-FG 2和786-O细胞系中释放。这些结果支持添加循环microRNA作为RCC的预后生物标志物。
Renal cell carcinoma (RCC) represents a challenge for clinicians since the nonexistence of screening and monitoring tests contributes to the fact that one-third of patients are diagnosed with metastatic disease and 20–40% of the remaining patients will also develop metastasis. Modern medicine is now trying to establish circulating biomolecules as the gold standard of biomarkers. Among the molecules that can be released from tumor cells we can find microRNAs. The aim of this study was to evaluate the applicability of cancer-related miR-210, miR-218, miR-221 and miR-1233 as prognostic biomarkers for RCC. Patients with higher levels of miR-210, miR-221 and miR-1233 presented a higher risk of specific death by RCC and a lower cancer-specific survival. The addition of miR-210, miR-221 and miR-1233 plasma levels information improved the capacity to predict death by cancer in 8, 4% when compared to the current variables used by clinicians. We also verified that hypoxia stimulates the release of miR-210 and miR-1233 from HKC-8, RCC-FG2 and 786-O cell lines. These results support the addition of circulating microRNAs as prognostic biomarkers for RCC.
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DOI：
10.4161/cc.9.6.11006
发表时间：
2010-03-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Chan SY;Loscalzo J
通讯作者：
Loscalzo J
影响因子：
1.6
作者：
Teixeira AL;Dias F;Gomes M;Fernandes M;Medeiros R
通讯作者：
Medeiros R
影响因子：
3.7
作者：
Duns, Gerben;van den Berg, Anke;Kok, Klaas
通讯作者：
Kok, Klaas
影响因子：
23.4
作者：
Schoedel, Johannes;Grampp, Steffen;Maher, Eamonn R.;Moch, Holger;Ratcliffe, Peter J.;Russo, Paul;Mole, David R.
通讯作者：
Mole, David R.
影响因子：
4.1
作者：
Faragalla, Hala;Youssef, Youssef M.;Yousef, George M.
通讯作者：
Yousef, George M.