Prenatal programing: at the intersection of maternal stress and immune activation.
Prenatal programing: at the intersection of maternal stress and immune activation.
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DOI：
10.1016/j.yhbeh.2012.03.007
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发表时间：
2012-08
影响因子：
3.5
通讯作者：
Bale, Tracy L.
中科院分区：
文献类型：
--
作者：
Howerton, Christopher L.;Bale, Tracy L.
关键词：
暴露于产前侮辱（例如母亲压力和病原体感染）与神经发育障碍的风险增加有关。除了胎儿性别和妊娠发育阶段等复合因素外，这些编程事件发生的机制可能还涉及母体激素环境、胎盘和发育中的胎儿之间复杂的相互作用。尽管涉及不同的生物过程，但对母体应激和免疫激活的常见途径的检查为阐明机制见解提供了有趣的可能性。此外，内分泌和性别特异性胎盘是一种组织，有望成为胎儿编程的关键介质，位于母体和胚胎环境的交叉点。在这篇综述中，我们将讨论母体应激和免疫途径激活的潜在共同机制，特别关注胎盘的重要贡献和作用。
Exposure to prenatal insults such as maternal stress and pathogenic infections has been associated with an increased risk for neurodevelopmental disorders. The mechanisms by which these programing events occur likely involve complex interactions between the maternal hormonal milieu, the placenta, and the developing fetus, in addition to compounding factors such as fetal sex and gestational stage of development. Despite the diverse biological processes involved, examination of common pathways in maternal stress and immune activation offers intriguing possibilities for elucidation of mechanistic insight. Further, the endocrine and sex-specific placenta is a tissue poised to be a key mediator in fetal programing, located at the intersection of the maternal and embryonic environments. In this review, we will discuss the potential shared mechanisms of maternal stress and immune pathway activation, with a particular focus on the important contribution and role of the placenta.
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影响因子：
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发表时间：
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