Cysteine-free proteins in the immunobiology of arthropod-borne diseases.
Cysteine-free proteins in the immunobiology of arthropod-borne diseases.
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DOI：
10.1155/2010/171537
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发表时间：
2010
影响因子：
--
通讯作者：
Titus RG
中科院分区：
文献类型：
--
作者：
Mejia JS;Arthun EN;Titus RG
鉴定可用于设计疫苗以同时控制几种节肢动物传播疾病的表位的一种方法是在引起它们的病原体的分泌组中寻找共同的结构特征。使用一种新的生物信息学技术，半胱氨酸丰度和分布分析，我们发现，许多不同的蛋白分泌的几种节肢动物传播的病原体，包括恶性疟原虫，伯氏疏螺旋体，和八种变形菌，是缺乏半胱氨酸残基。三个半胱氨酸的丰度和分布模式在几个家庭的蛋白质分泌的致病性和非致病性变形菌，并没有发现当分析的氨基酸是色氨酸的鉴定，提供了证据的力量限制在进化过程中的微生物蛋白质中的半胱氨酸残基的含量。我们讨论这些发现的背景下，蛋白质的结构和功能，抗原性和免疫原性，宿主-寄生虫的关系。
One approach to identify epitopes that could be used in the design of vaccines to control several arthropod-borne diseases simultaneously is to look for common structural features in the secretome of the pathogens that cause them. Using a novel bioinformatics technique, cysteine-abundance and distribution analysis, we found that many different proteins secreted by several arthropod-borne pathogens, including Plasmodium falciparum, Borrelia burgdorferi, and eight species of Proteobacteria, are devoid of cysteine residues. The identification of three cysteine-abundance and distribution patterns in several families of proteins secreted by pathogenic and nonpathogenic Proteobacteria, and not found when the amino acid analyzed was tryptophan, provides evidence of forces restricting the content of cysteine residues in microbial proteins during evolution. We discuss these findings in the context of protein structure and function, antigenicity and immunogenicity, and host-parasite relationships.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.2165/00822942-200403020-00005
发表时间：
2004-01-01
期刊：
Applied bioinformatics
影响因子：
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作者：
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通讯作者：
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