Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes.
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes.
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DOI：
10.1186/s40035-020-00221-2
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发表时间：
2020-11-26
影响因子：
12.6
通讯作者：
Koh SH
中科院分区：
文献类型：
--
作者：
Kwon HS;Koh SH
神经炎症与神经退行性疾病相关，如阿尔茨海默病、帕金森病和肌萎缩侧索硬化症。小胶质细胞和星形胶质细胞是中枢神经系统炎症反应的关键调节因子。小胶质细胞和星形胶质细胞的活化是异质的，传统上被分类为神经毒性（M1-表型小胶质细胞和A1-表型星形胶质细胞）或神经保护性（M2-表型小胶质细胞和A2-表型星形胶质细胞）。然而，这种二分法的分类可能并不能反映小胶质细胞和星形胶质细胞的各种表型。这些活化的胶质细胞之间的关系也非常复杂，并且表型分布可以根据神经退行性疾病的进展而改变。更好地理解小胶质细胞和星形胶质细胞在神经退行性疾病中的作用对于开发有效的治疗方法至关重要。本文就炎症反应在神经退行性疾病中的作用进行综述，重点介绍小胶质细胞和星形胶质细胞的作用及其相互关系。此外，我们还讨论了测量神经炎症的生物标志物和可以调节神经炎症的治疗药物的研究。
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The activation of microglia and astrocytes is heterogeneous and traditionally categorized as neurotoxic (M1-phenotype microglia and A1-phenotype astrocytes) or neuroprotective (M2-phenotype microglia and A2-phenotype astrocytes). However, this dichotomized classification may not reflect the various phenotypes of microglia and astrocytes. The relationship between these activated glial cells is also very complicated, and the phenotypic distribution can change, based on the progression of neurodegenerative diseases. A better understanding of the roles of microglia and astrocytes in neurodegenerative diseases is essential for developing effective therapies. In this review, we discuss the roles of inflammatory response in neurodegenerative diseases, focusing on the contributions of microglia and astrocytes and their relationship. In addition, we discuss biomarkers to measure neuroinflammation and studies on therapeutic drugs that can modulate neuroinflammation.
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影响因子：
34.7
作者：
Clarke, Laura E.;Barres, Ben A.
通讯作者：
Barres, Ben A.
影响因子：
3.3
作者：
Bekris LM;Khrestian M;Dyne E;Shao Y;Pillai JA;Rao SM;Bemiller SM;Lamb B;Fernandez HH;Leverenz JB
通讯作者：
Leverenz JB
DOI：
10.1093/brain/awr074
发表时间：
2011-05
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Beers DR;Henkel JS;Zhao W;Wang J;Huang A;Wen S;Liao B;Appel SH
通讯作者：
Appel SH
DOI：
10.1177/1073858413504465
发表时间：
2014-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Fields RD;Araque A;Johansen-Berg H;Lim SS;Lynch G;Nave KA;Nedergaard M;Perez R;Sejnowski T;Wake H
通讯作者：
Wake H
影响因子：
6.2
作者：
Familian, A;Boshuizen, RS;Veerhuis, R
通讯作者：
Veerhuis, R