Can nanoparticles and nano‒protein interactions bring a bright future for insulin delivery?
Can nanoparticles and nano‒protein interactions bring a bright future for insulin delivery?
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纳米粒子和纳米蛋白质的相互作用能为胰岛素输送带来光明的未来吗？
DOI：
10.1016/j.apsb.2020.08.016
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Peng Q
中科院分区：
文献类型：
--
作者：
Zhang T;Tang JZ;Fei X;Li Y;Song Y;Qian Z;Peng Q
胰岛素治疗在糖尿病的治疗中起着至关重要的作用。然而，有效控制血糖水平所需的频繁注射导致相当大的不便和低患者依从性。为了改善胰岛素的释放，人们做了许多努力，例如开发基于纳米颗粒（NPs）的释放系统和口服胰岛素。虽然已经取得了一些进展，但最终的结果仍然不令人满意，迄今为止还没有一种胰岛素负载的纳米粒系统被批准用于临床。近年来，由于纳米颗粒与蛋白质的相互作用和蛋白质冠状结构的形成对纳米颗粒系统在体内的命运产生负面影响，引起了人们的广泛关注。作为硬币的另一面，这种相互作用也可以用于构建先进的药物递送系统。在此，我们的目的是提供一个深入了解的进步和缺陷的各种纳米粒子为基础的胰岛素输送系统。特别是，一个有趣的讨论纳米蛋白质的相互作用和开发新的胰岛素给药系统的潜力。基于纳米颗粒的系统在递送胰岛素方面显示出巨大的潜力，但仍然存在一些局限性。纳米蛋白质相互作用，包括胰岛素与纳米材料的相互作用以及胰岛素负载纳米颗粒与其他蛋白质之间的相互作用，可能为先进的胰岛素输送提供未来的方向。胰岛素治疗在糖尿病治疗中起着重要作用。优化胰岛素输注增强胰岛素治疗。纳米颗粒是用于递送胰岛素的有前途的系统。纳米蛋白相互作用影响纳米颗粒的递送。纳米蛋白相互作用可用于胰岛素的高级递送。
Insulin therapy plays an essential role in the treatment of diabetes mellitus. However, frequent injections required to effectively control the glycemic levels lead to substantial inconvenience and low patient compliance. In order to improve insulin delivery, many efforts have been made, such as developing the nanoparticles (NPs)-based release systems and oral insulin. Although some improvements have been achieved, the ultimate results are still unsatisfying and none of insulin-loaded NPs systems have been approved for clinical use so far. Recently, nano‒protein interactions and protein corona formation have drawn much attention due to their negative influence on the in vivo fate of NPs systems. As the other side of a coin, such interactions can also be used for constructing advanced drug delivery systems. Herein, we aim to provide an insight into the advance and flaws of various NPs-based insulin delivery systems. Particularly, an interesting discussion on nano‒protein interactions and its potentials for developing novel insulin delivery systems is initiated. Nanoparticles-based systems have shown great potentials in delivering insulin but still have some limitations. Nano‒protein interactions, including the interaction of insulin with nanomaterials and between insulin-loaded nanoparticles and other proteins, may provide a future direction for advanced insulin delivery. Insulin therapy plays essential roles in treating diabetes. Optimizing insulin delivery enhances insulin therapy. Nanoparticles are promising systems for delivery of insulin. Nano-protein interactions influence the delivery of nanoparticles. Nano-protein interactions can be used for advanced delivery of insulin.
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