Diagnostic performance of the IMMY cryptococcal antigen lateral flow assay on serum and cerebrospinal fluid for diagnosis of cryptococcosis in HIV-negative patients: a systematic review.
Diagnostic performance of the IMMY cryptococcal antigen lateral flow assay on serum and cerebrospinal fluid for diagnosis of cryptococcosis in HIV-negative patients: a systematic review.
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DOI：
10.1186/s12879-023-08135-w
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发表时间：
2023-04-06
影响因子：
3.7
通讯作者：
Jarvis, Joseph N.
中科院分区：
文献类型：
--
作者：
Macrae, Catriona;Ellis, Jayne;Keddie, Suzanne H.;Falconer, Jane;Bradley, John;Keogh, Ruth;Baerenbold, Oliver;Hopkins, Heidi;Jarvis, Joseph N.
关键词：
在艾滋病毒阴性者中，隐球菌病的发病率正在增加。虽然CRAG检测在艾滋病毒携带者中的出色表现得到了很好的描述，但CRAG LFA在血清或脑脊液HIV阴性队列中的诊断性能尚未得到系统评估。我们对IMMY CRAG®LFA在HIV阴性人群血清和脑脊液中的诊断性能进行了系统评价。使用Medline、Embase、Global Health、CENTER、WOS科学引文索引、SCOPUS、全非洲信息、Lilacs和世卫组织全球卫生图书馆进行了系统的电子搜索。由两位独立的评价者筛选研究并从符合条件的研究中提取数据。采用固定效应荟萃分析评价诊断的敏感性和特异性。在评估合格的447项记录中，有9项研究符合我们的纳入标准，包括528名参与者。在评估IMMY CRAG®LFA对血清诊断性能的8项研究中，合并中值灵敏度为96%(95%可信区间(CRI)68-100%)，合并特异度估计为96%(95%CRI 84-100%)。在评估IMMY CRAG®LFA对脑脊液诊断性能的6项研究中，合并中位数灵敏度为99%(95%CRI 95-100%)，合并特异度中位数为99%(95%CRI 95-100%)。这篇综述展示了IMMY CRAG®LFA在HIV阴性人群中的高度敏感性和特异性，与HIV阳性个体的研究结果一致。由于研究数量较少，这项审查受到了限制。在HIV阴性人群中使用IMMY CRAG®LFA的进一步研究将有助于更好地确定该检测的诊断价值。网上版载有补充材料，可在10.1186/s12879-023-08135-w查阅。
The incidence of cryptococcosis amongst HIV-negative persons is increasing. Whilst the excellent performance of the CrAg testing in people living with HIV is well described, the diagnostic performance of the CrAg LFA has not been systematically evaluated in HIV-negative cohorts on serum or cerebrospinal fluid. We performed a systematic review to characterise the diagnostic performance of IMMY CrAg® LFA in HIV-negative populations on serum and cerebrospinal fluid. A systematic electronic search was performed using Medline, Embase, Global Health, CENTRAL, WoS Science Citation Index, SCOPUS, Africa-Wide Information, LILACS and WHO Global Health Library. Studies were screened and data extracted from eligible studies by two independent reviewers. A fixed effect meta-analysis was used to estimate the diagnostic sensitivity and specificity. Of 447 records assessed for eligibility, nine studies met our inclusion criteria, including 528 participants overall. Amongst eight studies that evaluated the diagnostic performance of the IMMY CrAg® LFA on serum, the pooled median sensitivity was 96% (95% Credible Interval (CrI) 68–100%) with a pooled specificity estimate of 96% (95%CrI 84–100%). Amongst six studies which evaluated the diagnostic performance of IMMY CrAg® LFA on CSF, the pooled median sensitivity was 99% (95%CrI 95–100%) with a pooled specificity median of 99% (95%CrI 95–100%). This review demonstrates a high pooled sensitivity and specificity for the IMMY CrAg® LFA in HIV-negative populations, in keeping with findings in HIV-positive individuals. The review was limited by the small number of studies. Further studies using IMMY CrAg® LFA in HIV-negative populations would help to better determine the diagnostic value of this test. The online version contains supplementary material available at 10.1186/s12879-023-08135-w.
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影响因子：
3.7
作者：
Jullien, Sophie;Fitzgerald, Felicity;Keddie, Suzanne;Baerenbold, Oliver;Bassat, Quique;Bradley, John;Falconer, Jane;Fink, Colin;Keogh, Ruth;Hopkins, Heidi;Voice, Marie
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通讯作者：
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影响因子：
1.9
作者：
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通讯作者：
Joseph, L
影响因子：
3.7
作者：
Min, Jingqi;Huang, Kunlun;Deng, Huojin
通讯作者：
Deng, Huojin