Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis.
Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis.
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DOI：
10.1186/s12879-022-07766-9
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发表时间：
2022-10-13
影响因子：
3.7
通讯作者：
Voice, Marie
中科院分区：
文献类型：
--
作者：
Jullien, Sophie;Fitzgerald, Felicity;Keddie, Suzanne;Baerenbold, Oliver;Bassat, Quique;Bradley, John;Falconer, Jane;Fink, Colin;Keogh, Ruth;Hopkins, Heidi;Voice, Marie
呼吸道合胞病毒（RSV）和流感病毒是全球发病率和死亡率的重要原因。我们评价了Luminex NxTAG呼吸道病原体检测试剂盒（RPPs）™（索引）与其他RPPs（对照）检测RSV和流感病毒的诊断准确性。纳入了比较使用索引和至少一种对照试验检测的人类临床呼吸道样本的研究。进行了随机效应潜在类别荟萃分析，以评估RSV和流感指数检测的特异性和灵敏度。使用QUADAS-2工具评估偏倚风险，使用GRADE评估证据确定性。纳入了10项研究。对于RSV，预测灵敏度为99%（95%可信区间[CrI] 96-100%），特异性为100%（95% CrI 98-100%）。对于甲型和B型流感，预测灵敏度分别为97%（95% CrI 89-100）和98%（95% CrI 88-100）;特异性分别为100%（95% CrI 99-100）和100%（95% CrI 99-100）。证据的确定性很低。虽然指数的敏感性和特异性都很好，但比较者的表现各不相同。进一步研究明确的患者招募策略可以确定不同人群的表现。方案注册：Prospero CRD 42021272062。在线版本包含补充材料，可通过10.1186/s12879-022-07766-9获得。
Respiratory syncytial virus (RSV) and influenza viruses are important global causes of morbidity and mortality. We evaluated the diagnostic accuracy of the Luminex NxTAG respiratory pathogen panels (RPPs)™ (index) against other RPPs (comparator) for detection of RSV and influenza viruses. Studies comparing human clinical respiratory samples tested with the index and at least one comparator test were included. A random-effect latent class meta-analysis was performed to assess the specificity and sensitivity of the index test for RSV and influenza. Risk of bias was assessed using the QUADAS-2 tool and certainty of evidence using GRADE. Ten studies were included. For RSV, predicted sensitivity was 99% (95% credible interval [CrI] 96–100%) and specificity 100% (95% CrI 98–100%). For influenza A and B, predicted sensitivity was 97% (95% CrI 89–100) and 98% (95% CrI 88–100) respectively; specificity 100% (95% CrI 99–100) and 100% (95% CrI 99–100), respectively. Evidence was low certainty. Although index sensitivity and specificity were excellent, comparators’ performance varied. Further research with clear patient recruitment strategies could ascertain performance across different populations. Protocol Registration: Prospero CRD42021272062. The online version contains supplementary material available at 10.1186/s12879-022-07766-9.
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影响因子：
7.2
作者：
Schunemann, Holger J.;Mustafa, Reem A.;Guyatt, Gordon H.
通讯作者：
Guyatt, Gordon H.
影响因子：
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Gonsalves, Sarah;Mahony, James;Juretschko, Stefan
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Juretschko, Stefan
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作者：
O'Brien, Katherine L.;Levine, Orin S.;Mitchell, Joanne L.
通讯作者：
Mitchell, Joanne L.
DOI：
10.1016/j.diagmicrobio.2019.114880
发表时间：
2019-12-01
影响因子：
2.9
作者：
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通讯作者：
Stefanovic, Aleksandra
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9.4
作者：
Brotons, Pedro;Henares, Desiree;Munoz-Almagro, Carmen
通讯作者：
Munoz-Almagro, Carmen