Time-frequency methods and voluntary ramped-frequency breathing: a powerful combination for exploration of human neurophysiological mechanisms.
Time-frequency methods and voluntary ramped-frequency breathing: a powerful combination for exploration of human neurophysiological mechanisms.
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时频方法和自愿斜坡频率呼吸：探索人类神经生理学机制的强大组合。
DOI：
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发表时间：
2013
影响因子：
3.3
通讯作者：
D. Eckberg
中科院分区：
文献类型：
--
作者：
T. Stankovski;W. Cooke;L. Rudas;A. Stefanovska;D. Eckberg
我们实验性地改变呼吸运动神经元活动的时间，作为一种手段来调节和更好地理解，否则隐藏的人类中枢神经和血流动力学振荡机制。我们记录了心电图，手指光电容积脉搏波动脉压，潮气二氧化碳浓度，和肌肉交感神经活动在13个健康的仰卧位的年轻男子逐渐增加或减少他们的呼吸频率之间的0.05和0.25赫兹超过9分钟的时间。我们分析了传统的时域和频域方法的结果，也与时频方法（小波变换，小波相位相干，方向耦合）。我们确定了统计意义，并确定了频率的界限，通过比较测量与随机生成的替代品。我们的研究结果支持几个主要结论。首先，呼吸在很宽的频率范围内因果地调节交感神经（弱）和迷走神经运动神经元（强）的振荡，这个频率范围远低于实际呼吸的频率。第二，呼吸频率广泛地调节迷走神经压力反射增益，峰值增益在低频范围内记录。第三，呼吸频率不影响交感神经或迷走神经活动随时间的中值水平。第四，动脉压和交感神经和迷走神经运动神经元之间的相位关系不受呼吸的影响，因此可能是次要的内在反应，这些运动神经元的其他突触输入。最后，呼吸频率不影响舒张压和肌肉交感神经振荡之间的相位相干性，但它在通常呼吸频率范围的有限部分上增强收缩压和R-R间期振荡之间的相位相干性。这些结果完善了对自主振荡过程和被称为人类呼吸门的生理机制的理解。
We experimentally altered the timing of respiratory motoneuron activity as a means to modulate and better understand otherwise hidden human central neural and hemodynamic oscillatory mechanisms. We recorded the electrocardiogram, finger photoplethysmographic arterial pressure, tidal carbon dioxide concentrations, and muscle sympathetic nerve activity in 13 healthy supine young men who gradually increased or decreased their breathing frequencies between 0.05 and 0.25 Hz over 9-min periods. We analyzed results with traditional time- and frequency-domain methods, and also with time-frequency methods (wavelet transform, wavelet phase coherence, and directional coupling). We determined statistical significance and identified frequency boundaries by comparing measurements with randomly generated surrogates. Our results support several major conclusions. First, respiration causally modulates both sympathetic (weakly) and vagal motoneuron (strongly) oscillations over a wide frequency range-one that extends well below the frequency of actual breaths. Second, breathing frequency broadly modulates vagal baroreflex gain, with peak gains registered in the low frequency range. Third, breathing frequency does not influence median levels of sympathetic or vagal activity over time. Fourth, phase relations between arterial pressure and sympathetic and vagal motoneurons are unaffected by breathing, and are therefore likely secondary to intrinsic responsiveness of these motoneurons to other synaptic inputs. Finally, breathing frequency does not affect phase coherence between diastolic pressure and muscle sympathetic oscillations, but it augments phase coherence between systolic pressure and R-R interval oscillations over a limited portion of the usual breathing frequency range. These results refine understanding of autonomic oscillatory processes and those physiological mechanisms known as the human respiratory gate.
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人类肌肉交感神经活动中与心脏相关的节律的基础。
DOI：
10.1152/ajpheart.00602.2002
发表时间：
2003
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Barman,SusanM;Fadel,PaulJ;Vongpatanasin,Wanpen;Victor,RonaldG;Gebber,GerardL
通讯作者：
Gebber,GerardL
CO2 化学反射和动脉压力反射之间的相互作用。
DOI：
10.1152/ajpheart.1998.274.6.h2177
发表时间：
1998
期刊：
The American journal of physiology.
影响因子：
--
作者：
Henry,RA;Lu,IL;Beightol,LA;Eckberg,DL
通讯作者：
Eckberg,DL
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
影响因子：
--
作者：
HASELTON, JR;GUYENET, PG
通讯作者：
GUYENET, PG
影响因子：
3.3
作者：
BROWN, TE;BEIGHTOL, LA;ECKBERG, DL
通讯作者：
ECKBERG, DL