Basis for the cardiac-related rhythm in muscle sympathetic nerve activity of humans.

Basis for the cardiac-related rhythm in muscle sympathetic nerve activity of humans.
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人类肌肉交感神经活动中与心脏相关的节律的基础。

DOI:
10.1152/ajpheart.00602.2002
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发表时间:
2003
期刊:
American journal of physiology. Heart and circulatory physiology
影响因子:
--
通讯作者:
Gebber,GerardL
Gebber,GerardL
中科院分区:
--
文献类型:
--
作者:
Barman,SusanM;Fadel,PaulJ;Vongpatanasin,Wanpen;Victor,RonaldG;Gebber,GerardL

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我们测试了人体肌肉交感神经活动(MSNA)的心脏相关节律反映了脉冲同步压力感受器神经活动对中央振荡器的干扰这一假设。部分自谱分析用于从数学上去除MSNA自谱中归因于其与ECG线性关系的心脏相关功率部分。在98例患者中,有54例在心电图局部化后仍保留≥15%的心脏相关功率;峰值剩余心脏相关功率的频率通常与心率不同。当以心脏相关的每次爆发为基础进行评估时,4名受试者在呼吸时间尺度上的ECG-MSNA间隔(从R波到心脏相关爆发峰值的延迟)存在进行性和周期性变化。在这些受试者中,以及一些时间间隔随机变化的受试者中,ECG-MSNA时间间隔与心脏相关的猝发幅度呈反比关系。然而,在45%的病例中,这些参数不相关。这些结果支持这样一种观点,即MSNA中与心脏相关的节律反映了非线性振荡器的强迫作用,而不是非结构化随机活动的周期性抑制。
We tested the hypothesis that the cardiac-related rhythm in muscle sympathetic nerve activity (MSNA) of humans reflects entrainment of a central oscillator by pulse-synchronous baroreceptor nerve activity. Partial autospectral analysis was used to mathematically remove the portion of cardiac-related power in MSNA autospectra that was attributable to its linear relationship to the ECG. In 54 of 98 cases, ≥15% of cardiac-related power remained after partialization with the ECG; peak residual cardiac-related power was often at a frequency different than heart rate. When assessed on a cardiac-related burst-by-burst basis, there was a progressive and cyclic change in the ECG-MSNA interval (delay from R wave to peak of cardiac-related burst) on the time scale of respiration in four subjects. In these subjects, as well as in some in which the interval appeared to change randomly, there was an inverse relationship between the ECG-MSNA interval and cardiac-related burst amplitude. However, in 45% of the cases, these parameters were not related. These results support the view that the cardiac-related rhythm in MSNA reflects forcing of a nonlinear oscillator rather than periodic inhibition of unstructured, random activity.
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