Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity.
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity.
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DOI：
10.1016/j.molcel.2021.08.027
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发表时间：
2021-09-16
期刊：
影响因子：
16
通讯作者：
Greka A
中科院分区：
文献类型：
--
作者：
Yoon H;Shaw JL;Haigis MC;Greka A
脂质在信号转导中起着至关重要的作用，有助于细胞膜的结构完整性，并调节能量代谢。关于哪些脂质物种维持代谢动态平衡以及哪些破坏基本细胞功能导致代谢紊乱的问题仍然存在。在这里，我们讨论了最近的进展，了解脂代谢的重点是分解代谢，合成和信号。包括功能基因组学、代谢组学、脂类组学、脂-蛋白相互作用图谱和质谱学方面的技术进步揭示了优先考虑调节脂质功能的分子机制的新方法。通过回顾已知的特定脂类在生理途径中的不同作用，我们为理解新发现的调节脂类稳态的靶点提供了一个框架，这对改善代谢性疾病具有重要意义。Yoon等人讨论了脂代谢方面的最新进展，重点是分解代谢、合成和信号转导。作者从功能基因组学、代谢组学、脂类组学、脂-蛋白相互作用图谱和质谱学的最新技术进展的角度，讨论了优先考虑调节脂质功能的分子机制的新方法。
Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular membranes, and regulate energy metabolism. Questions remain as to which lipid species maintain metabolic homeostasis and which disrupt essential cellular functions leading to metabolic disorders. Here we discuss recent advances in understanding lipid metabolism with a focus on catabolism, synthesis, and signaling. Technical advances including functional genomics, metabolomics, lipidomics, lipid-protein interaction maps, and advances in mass spectrometry have uncovered new ways to prioritize molecular mechanisms mediating lipid function. By reviewing what is known about the distinct effects of specific lipid species in physiological pathways, we provide a framework for understanding newly identified targets regulating lipid homeostasis with implications for ameliorating metabolic diseases. Yoon et al., discuss recent advances in understanding lipid metabolism with a focus on catabolism, synthesis, and signaling. Through the lens of recent technical advances including functional genomics, metabolomics, lipidomics, lipid-protein interaction maps, and advances in mass spectrometry, the authors discuss new ways to prioritize molecular mechanisms mediating lipid function.
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影响因子：
3.5
作者：
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通讯作者：
Drackley, J. K.
影响因子：
16
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影响因子：
3.2
作者：
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通讯作者：
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影响因子：
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作者：
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