A glimpse into the future - Personalized medicine for smoking cessation.
A glimpse into the future - Personalized medicine for smoking cessation.
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DOI：
10.1016/j.neuropharm.2013.09.009
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发表时间：
2014-01
影响因子：
4.7
通讯作者：
Saccone NL
中科院分区：
文献类型：
--
作者：
Bierut LJ;Johnson EO;Saccone NL
吸烟对个人和社会造成的破坏性后果促使研究人员确定和了解驱动吸烟行为的生物学途径，以便开发更有效的预防和治疗方法。吸烟者以不同的方式对尼古丁产生反应，少数吸烟者终生保持低水平吸烟，从未表现出任何依赖症状，而更多的人会对尼古丁产生依赖。吸烟者是否转变为尼古丁依赖具有明确的遗传贡献，编码α5-α3-β4烟碱受体亚基的基因变异对吸烟者之间发生尼古丁依赖的风险差异影响最大。最近的工作揭示了基于α5-α3-β4烟碱受体基因簇中这些相同的遗传变异对戒烟药物治疗的不同反应。我们预计，基因发现转化为更成功的戒烟治疗的速度将继续加快。鉴于美国每年有40多万人和全世界每年有500多万人死于与吸烟有关的疾病，提高对吸烟行为和戒烟机制的认识必须成为公共卫生的优先事项，以便我们能够在公共卫生层面和个人层面进行最佳干预。
The devastating consequences of tobacco smoking for individuals and societies motivate studies to identify and understand the biological pathways that drive smoking behaviors, so that more effective preventions and treatments can be developed. Cigarette smokers respond to nicotine in different ways, with a small number of smokers remaining lifelong low-level smokers who never exhibit any symptoms of dependence, and a larger group becoming nicotine dependent. Whether or not a smoker transitions to nicotine dependence has clear genetic contributions, and variants in the genes encoding the α5-α3-β4 nicotinic receptor subunits most strongly contribute to differences in the risk for developing nicotine dependence among smokers. More recent work reveals a differential response to pharmacologic treatment for smoking cessation based on these same genetic variants in the α5-α3-β4 nicotinic receptor gene cluster. We anticipate a continuing acceleration of the translation of genetic discoveries into more successful treatment for smoking cessation. Given that over 400,000 people in the United States and over 5 million people world-wide die each year from smoking related illnesses, an improved understanding of the mechanisms underlying smoking behavior and smoking cessation must be a high public health priority so we can best intervene at both the public health level and the individual level.
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DOI：
10.1158/1940-6207.capr-10-0362
发表时间：
2011-05
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Hamidovic A;Kasberger JL;Young TR;Goodloe RJ;Redline S;Buxbaum SG;Benowitz NL;Bergen AW;Butler KR;Franceschini N;Gharib SA;Hitsman B;Levy D;Meng Y;Papanicolaou GJ;Preis SR;Spring B;Styn MA;Tong EK;White WB;Wiggins KL;Jorgenson E
通讯作者：
Jorgenson E
影响因子：
5.2
作者：
Bondy, S. J.;Victor, J. C.;Diemert, L. M.
通讯作者：
Diemert, L. M.
烟碱乙酰胆碱受体β2亚基基因与基于系统的候选戒烟基因研究有关。
影响因子：
3.5
作者：
Conti, David V.;Lee, Won;Li, Dalin;Liu, Jinghua;Van Den Berg, David;Thomas, Paul D.;Bergen, Andrew W.;Swan, Gary E.;Tyndale, Rachel F.;Benowitz, Neal L.;Lerman, Caryn
通讯作者：
Lerman, Caryn
影响因子：
--
作者：
Hartz, Sarah M.;Short, Susan E.;Saccone, Nancy L.;Culverhouse, Robert;Chen, LiShiun;Schwantes-An, Tae-Hwi;Coon, Hilary;Han, Younghun;Stephens, Sarah H.;Sun, Juzhong;Chen, Xiangning;Ducci, Francesca;Dueker, Nicole;Franceschini, Nora;Frank, Josef;Geller, Frank;Guobjartsson, Daniel;Hansel, Nadia N.;Jiang, Chenhui;Keskitalo-Vuokko, Kaisu;Liu, Zhen;Lyytikainen, Leo-Pekka;Michel, Martha;Rawal, Rajesh;Hum, Sc;Rosenberger, Albert;Scheet, Paul;Shaffer, John R.;Teumer, Alexander;Thompson, John R.;Vink, Jacqueline M.;Vogelzangs, Nicole;Wenzlaff, Angela S.;Wheeler, William;Xiao, Xiangjun;Yang, Bao-Zhu;Aggen, Steven H.;Balmforth, Anthony J.;Baumeister, Sebastian E.;Beaty, Terri;Bennett, Siiri;Bergen, Andrew W.;Boyd, Heather A.;Broms, Ulla;Campbell, Harry;Chatterjee, Nilanjan;Chen, Jingchun;Cheng, Yu-Ching;Cichon, Sven;Couper, David;Cucca, Francesco;Dick, Danielle M.;Foroud, Tatiana;Furberg, Helena;Giegling, Ina;Gu, Fangyi;Hall, Alistair S.;Hallfors, Jenni;Han, Shizhong;Hartmann, Annette M.;Hayward, Caroline;Heikkila, Kauko;Hewitt, John K.;Hottenga, Jouke Jan;Jensen, Majken K.;Jousilahti, Pekka;Kaakinen, Marika;Kittner, Steven J.;Konte, Bettina;Korhonen, Tellervo;Landi, Maria-Teresa;Laatikainen, Tiina;Leppert, Mark;Levy, Steven M.;Mathias, Rasika A.;McNeil, Daniel W.;Medland, Sarah E.;Montgomery, Grant W.;Muley, Thomas;Murray, Tanda;Nauck, Matthias;North, Kari;Pergadia, Michele;Polasek, Ozren;Ramos, Erin M.;Ripatti, Samuli;Risch, Angela;Ruczinski, Ingo;Rudan, Igor;Salomaa, Veikko;Schlessinger, David;Styrkarsdottir, Unnur;Terracciano, Antonio;Uda, Manuela;Willemsen, Gonneke;Wu, Xifeng;Abecasis, Goncalo;Barnes, Kathleen;Bickeboeller, Heike;Boerwinkle, Eric;Boomsma, Dorret I.;Caporaso, Neil;Duan, Jubao;Edenberg, Howard J.;Francks, Clyde;Gejman, Pablo V.;Gelernter, Joel;Grabe, Hans Joergen;Hops, Hyman;Jarvelin, Marjo-Riitta;Viikari, Jorma;Kahonen, Mika;Kendler, Kenneth S.;Lehtimaki, Terho;Levinson, Douglas F.;Marazita, Mary L.;Marchini, Jonathan;Melbye, Mads;Mitchell, Braxton D.;Murray, Jeffrey C.;Nothen, Markus M.;Penninx, Brenda W.;Raitakari, Olli;Rietschel, Marcella;Rujescu, Dan;Samani, Nilesh J.;Sanders, Alan R.;Schwartz, Ann G.;Shete, Sanjay;Shi, Jianxin;Spitz, Margaret;Stefansson, Kari;Swan, Gary E.;Thorgeirsson, Thorgeir;Volzke, Henry;Wei, Qingyi;Wichmann, H. -Erich;Amos, Christopher I.;Breslau, Naomi;Cannon, Dale S.;Ehringer, Marissa;Grucza, Richard;Hatsukami, Dorothy;Heath, Andrew;Johnson, Eric O.;Kaprio, Jaakko;Madden, Pamela;Martin, Nicholas G.;Stevens, Victoria L.;Stitzel, Jerry A.;Weiss, Robert B.;Kraft, Peter;Bierut, Laura J.
通讯作者：
Bierut, Laura J.
影响因子：
64.8
作者：
Fowler, Christie D.;Lu, Qun;Johnson, Paul M.;Marks, Michael J.;Kenny, Paul J.
通讯作者：
Kenny, Paul J.