Critical effects of long non-coding RNA on fibrosis diseases.

Critical effects of long non-coding RNA on fibrosis diseases.
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长链非编码 RNA 对纤维化疾病的关键影响。

DOI:
10.1038/emm.2017.223
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发表时间:
2018-01-19
影响因子:
12.8
通讯作者:
Tang J
Tang J
中科院分区:
医学2区
文献类型:
--
作者:
Zhang Y;Luo G;Zhang Y;Zhang M;Zhou J;Gao W;Xuan X;Yang X;Yang D;Tian Z;Ni B;Tang J

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长链非编码RNA(lncRNA)的表达或功能障碍与多种遗传性疾病、自身免疫性疾病、代谢性疾病和肿瘤密切相关。LncRNA最近也被认为是纤维化的功能调节剂,纤维化是许多这些疾病中的继发过程和纤维化疾病中的主要病理。本文就lncRNA在肝、心肌、肾、肺和腹膜纤维化疾病中的最新研究进展作一综述。我们还讨论了疾病相关的lncRNA作为人类纤维化疾病临床治疗的治疗靶点的潜力。
The expression or dysfunction of long non-coding RNAs (lncRNAs) is closely related to various hereditary diseases, autoimmune diseases, metabolic diseases and tumors. LncRNAs were also recently recognized as functional regulators of fibrosis, which is a secondary process in many of these diseases and a primary pathology in fibrosis diseases. We review the latest findings on lncRNAs in fibrosis diseases of the liver, myocardium, kidney, lung and peritoneum. We also discuss the potential of disease-related lncRNAs as therapeutic targets for the clinical treatment of human fibrosis diseases.
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