The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases.
The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases.
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DOI：
10.1186/s12989-016-0162-4
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发表时间：
2016-09-20
影响因子：
10
通讯作者：
Mossman BT
中科院分区：
文献类型：
--
作者：
Sayan M;Mossman BT
炎症小体的概念是大约十年前首次提出的，它是一种感知细胞压力或危险信号并引发炎症的大分子复合物。这些细胞内蛋白平台的启动和激活会触发促炎趋化因子和细胞因子的成熟，尤其是白细胞介素-1β (IL-1β) 和 IL-18，从而促进先天免疫防御。虽然经典研究是在痛风、II 型糖尿病、阿尔茨海默病和多发性硬化症模型中进行的，但最近在呼吸道细胞中阐明了炎症小体启动和激活的重要性和作用机制，它们调节对许多吸入的致病颗粒和纤维的反应。最值得注意的是，吸入石棉、结晶二氧化硅（CS）和空气颗粒物（PM）等致病污染物后，炎症小体激活似乎可以调节组织修复和炎症之间的平衡。不同类型的纤维和颗粒可能具有不同的炎症小体相互作用和结果机制。本综述总结了炎症小体的结构和功能、炎症小体激活后各种趋化因子和细胞因子与肺和胸膜细胞类型之间的相互作用，以及致病性颗粒导致非恶性（过敏性气道疾病和慢性阻塞性肺病（COPD）、石棉肺、矽肺）和恶性（间皮瘤、肺癌）疾病发展的事件。此外，它还强调了免疫系统细胞、这些疾病的靶细胞和细胞外基质 (ECM) 成分之间通讯在调节炎症体介导事件中的重要性。
The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately a decade ago. Priming and activation of these intracellular protein platforms trigger the maturation of pro-inflammatory chemokines and cytokines, most notably, interleukin-1β (IL-1β) and IL-18, to promulgate innate immune defenses. Although classically studied in models of gout, Type II diabetes, Alzheimer’s disease, and multiple sclerosis, the importance and mechanisms of action of inflammasome priming and activation have recently been elucidated in cells of the respiratory tract where they modulate the responses to a number of inhaled pathogenic particles and fibres. Most notably, inflammasome activation appears to regulate the balance between tissue repair and inflammation after inhalation of pathogenic pollutants such as asbestos, crystalline silica (CS), and airborne particulate matter (PM). Different types of fibres and particles may have distinct mechanisms of inflammasome interaction and outcome. This review summarizes the structure and function of inflammasomes, the interplay between various chemokines and cytokines and cell types of the lung and pleura after inflammasome activation, and the events leading to the development of non-malignant (allergic airway disease and chronic obstructive pulmonary disease (COPD), asbestosis, silicosis) and malignant (mesothelioma, lung cancer) diseases by pathogenic particulates. In addition, it emphasizes the importance of communication between cells of the immune system, target cells of these diseases, and components of the extracellular matrix (ECM) in regulation of inflammasome-mediated events.
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DOI：
10.2741/3782
发表时间：
2011-01-01
期刊：
Frontiers in bioscience (Landmark edition)
影响因子：
--
作者：
Chen W;Li Z;Bai L;Lin Y
通讯作者：
Lin Y
影响因子：
2.1
作者：
Brüske I;Hampel R;Socher MM;Rückerl R;Schneider A;Heinrich J;Oberdörster G;Wichmann HE;Peters A
通讯作者：
Peters A
影响因子：
11.5
作者：
Carbone, Michele;Yang, Haining
通讯作者：
Yang, Haining
影响因子：
10
作者：
BARIS, YI;SAHIN, AA;GOKTEPELI, A
通讯作者：
GOKTEPELI, A
影响因子：
3.9
作者：
CHAO, CC;AUST, AE
通讯作者：
AUST, AE