The development of the concept of ferroptosis.

The development of the concept of ferroptosis.
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DOI:
10.1016/j.freeradbiomed.2018.09.043
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发表时间:
2019-03
影响因子:
7.4
通讯作者:
Stockwell BR
Stockwell BR
中科院分区:
医学1区
文献类型:
--
作者:
Hirschhorn T;Stockwell BR

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The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of cell death caused by the accumulation of lipid-based reactive oxygen species; this type of cell death was found to have molecular characteristics distinct from other forms of regulated cell death. Features of ferroptosis have been observed periodically over the last several decades, but these molecular features were not recognized as evidence of a distinct form of cell death until recently. Here, we describe the history of observations consistent with the current definition of ferroptosis, as well as the advances that contributed to the emergence of the concept of ferroptosis. We also discuss recent implications and applications of manipulations of the ferroptotic death pathway.
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