Aromatic Polyketides from the Deep-Sea Cold-Seep Mussel Associated Endozoic Fungus Talaromyces minioluteus CS-138.
Aromatic Polyketides from the Deep-Sea Cold-Seep Mussel Associated Endozoic Fungus Talaromyces minioluteus CS-138.
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从小型拟青霉CS-138中分离鉴定了5个新的芳香族多酮化合物，包括一个独特的苯并呋喃类化合物塔拉罗明A(1)和4个色酮类似物塔拉明A-D(2-5)，以及一个已知的相关代谢物5-羟基-7-甲氧基-2，3-二甲基色酮(6)。通过对它们的核磁共振谱、HRESIMS和X-射线单晶数据的详细分析，并与文献数据进行比较，确定了它们的化学结构。对化合物1-6的抗菌活性和DPPH清除活性进行了评价。化合物1-3对部分供试细菌具有抑制活性，化合物2和5具有较强的清除DPPH自由基的活性，优于阳性对照丁基羟基甲苯(BHT)。这项工作很可能是关于生活在寒冷渗漏环境中的贻贝来源真菌的海洋天然产物的第一份报告。
Five new aromatic polyketides, including a unique benzofuran derivative, talarominine A (1), and four chromone analogs talamins A–D (2–5), along with one known related metabolite, 5-hydroxy-7-methoxy-2,3-dimethylchromone (6), were isolated and identified from the Talaromyces minioluteus CS-138, an endozoic fungus obtained from the deep-sea cold seep mussel Gigantidas platifrons. Their chemical structures were elucidated by detailed analysis of their NMR spectra, HRESIMS and X-ray crystallographic data, and by comparison with literature data as well. The antibacterial and DPPH scavenging activities of compounds 1–6 were evaluated. Compounds 1–3 showed inhibitory activity against some of the tested bacteria whereas compounds 2 and 5 showed potent DPPH radical scavenging activities, which were better than that of the positive control butylated hydroxytoluene (BHT). This work is likely the first report on marine natural products of mussel-derived fungus living in cold seep environments.
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影响因子：
8.8
作者：
Sharma, Om P.;Bhat, Tej K.
通讯作者：
Bhat, Tej K.
影响因子：
5.4
作者：
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影响因子：
5.4
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通讯作者：
Kittakoop P
影响因子：
5.1
作者：
Chi, Lu-Ping;Li, Xiao-Ming;Wang, Bin-Gui
通讯作者：
Wang, Bin-Gui
影响因子：
5.2
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Yan, Li-Hong;Li, Pei-Hai;Li, Xin
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