Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.
Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.
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DOI：
10.1038/nature10378
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发表时间：
2011-08-17
期刊：
影响因子：
64.8
通讯作者：
Bargmann, Cornelia I.
中科院分区：
文献类型：
--
作者：
McGrath, Patrick T.;Xu, Yifan;Ailion, Michael;Garrison, Jennifer L.;Butcher, Rebecca A.;Bargmann, Cornelia I.
进化可以遵循可预测的遗传轨迹，这表明离散的环境变化可以选择可复制的遗传变化。同种个体是动物环境的一个重要特征，也是选择压力的潜在来源。我们在这里展示了两个隐杆线虫物种对高密度生长的适应，这是家庭环境中常见的特征，是通过信息素受体基因的可复制遗传变化发生的。在高密度生长过程中，通过信息素积累的化学通讯使线虫幼虫进入寿命较长但无生殖能力的幼虫期。两株在高密度条件下生长的秀丽隐杆线虫独立获得了对信息素诱导的多基因抗性。在每个菌株中，对信息素ascaroside C3的抗性是由于邻近的化学受体基因蛇形素受体g类(srg)-36和-37的缺失。通过错表达实验，我们发现这些基因编码了多余的G蛋白偶联受体来表达天调素C3。在一种不同的线虫物种——绿杆线虫的高密度培养中，也出现了对水形成的多基因抗性，部分原因是与srg-36和srg-37相似的srg基因缺失。这些结果表明，化学受体库的快速重塑是对特定环境的适应，并表明对共同遗传底物的平行变化可以影响物种间的生活史特征。
Evolution can follow predictable genetic trajectories, indicating that discrete environmental shifts can select for reproducible genetic changes. Conspecific individuals are an important feature of an animal's environment, and a potential source of selective pressures. We show here that adaptation of two Caenorhabditis species to growth at high density, a feature common to domestic environments, occurs by reproducible genetic changes to pheromone receptor genes. Chemical communication through pheromones that accumulate during high-density growth causes young nematode larvae to enter the long-lived but non-reproductive dauer stage. Two strains of Caenorhabditis elegans grown at high density have independently acquired multigenic resistance to pheromone-induced dauer formation. In each strain, resistance to the pheromone ascaroside C3 results from a deletion that disrupts the adjacent chemoreceptor genes serpentine receptor class g (srg)-36 and -37. Through misexpression experiments, we show that these genes encode redundant G protein-coupled receptors for ascaroside C3. Multigenic resistance to dauer formation has also arisen in high-density cultures of a different nematode species, Caenorhabditis briggsae, resulting in part from deletion of an srg gene paralogous to srg-36 and srg-37. These results demonstrate rapid remodeling of the chemoreceptor repertoire as an adaptation to specific environments, and indicate that parallel changes to a common genetic substrate can affect life history traits across species.
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影响因子：
30.8
作者：
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