Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction.
Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction.
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DOI：
10.1007/s11682-016-9583-9
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发表时间：
2017-10
影响因子：
3.2
通讯作者：
Teng GJ
中科院分区：
文献类型：
--
作者：
Cui Y;Liang X;Gu H;Hu Y;Zhao Z;Yang XY;Qian C;Yang Y;Teng GJ
采用全脑动脉自旋标记（ASL）MRI技术，探讨2型糖尿病（T2 DM）对脑灌注的影响，以及脑灌注变化与认知功能障碍和糖尿病变量的关系。这项前瞻性研究获得了当地机构审查委员会的批准，并在2012年11月至2013年10月期间进行。所有受试者均提供知情同意书。纳入40例T2 DM患者和41例年龄、性别和教育程度匹配的健康对照。在3 T MRI上采用ASL脉冲灌注成像获得脑血流图.在两组之间进行了CBF图上的体素比较（有和没有部分容积效应（PVE）校正）。CBF和认知功能之间的关联，CBF和糖尿病变量之间的关系进行了研究，通过使用体素，全脑相关分析。2型糖尿病患者的PVE未校正CBF在后扣带回皮质（PCC）、楔前叶和双侧枕叶减少，而在前扣带回皮质增加（校正P <0.05）。这些变化在PVE校正后基本不变。相关性分析显示，在患者中，PCC和楔前叶区域的低灌注与较高的胰岛素抵抗水平和绘制时钟性能的缺陷相关，而枕叶低灌注与视觉记忆性能较差相关，无论PVE校正如何。T2 DM患者的脑灌注不足模式与痴呆早期观察到的模式相似，胰岛素抵抗增加可能是此类CBF失调的重要风险因素和治疗靶点。本文的在线版本（doi：10.1007/s11682-016-9583-9）包含补充材料，可供授权用户使用。
To explore the effect of T2DM on cerebral perfusion, and the relationship between cerebral perfusion changes and cognitive impairment as well as diabetic variables, by using a whole-brain arterial spin-labeling (ASL) MRI technique. This prospective study was approved by the local institutional review board and was performed between November 2012 and October 2013. All subjects provided informed consent. Forty T2DM patients and 41 age-, sex- and education-matched healthy controls were included. Cerebral blood flow (CBF) map was obtained by pulsed ASL perfusion imaging at 3 T MRI. Voxel-wise comparisons on CBF maps with and without partial volume effects (PVEs) correction were performed between groups. Associations between CBF and cognitive functioning, and between CBF and diabetic variables were investigated by using voxel-wise, whole-brain correlation analyses. In T2DM patients, PVEs uncorrected CBF was decreased in the posterior cingulate cortex (PCC), precuneus and bilateral occipital lobe, and increased in the anterior cingulate cortex (corrected P < .05). These changes were largely unchanged after PVEs correction. Correlation analyses revealed that in patients, hypoperfusion in PCC and precuneus regions were related to higher insulin resistance level and deficits in clock-drawing performance, while the occipital hypoperfusion was associated with worse visual-memory performance, regardless of PVEs correction. The cerebral hypoperfusion pattern in T2DM resembles the pattern observed in the early stage of dementia, and increased insulin resistance might be an important risk factor as well as treatment target for such CBF dysregulation. The online version of this article (doi:10.1007/s11682-016-9583-9) contains supplementary material, which is available to authorized users.
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影响因子：
3
作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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3.5
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DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
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