Cancer risk in hospitalised psoriasis patients: a follow-up study in Sweden.

Cancer risk in hospitalised psoriasis patients: a follow-up study in Sweden.
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DOI:
10.1038/sj.bjc.6605027
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发表时间:
2009-05-05
影响因子:
8.8
通讯作者:
Hemminki, K.
Hemminki, K.
中科院分区:
医学1区
文献类型:
--
作者:
Ji, J.;Shu, X.;Sundquist, K.;Sundquist, J.;Hemminki, K.

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我们检查了因牛皮癣住院一次或多次的瑞典受试者的总体和特定癌症风险。通过从瑞典医院出院登记簿中确定这类患者并将其与癌症登记处联系起来,建立了一个数据库。对患者进行随访,从最后一次住院到2004年。1965年至2004年期间,共有15858名牛皮癣患者住院,其中1408人发展为癌症,总体标准化发病率(SIRs)为1.33。鳞状细胞皮肤癌、上呼吸道消化道、食道癌、胃癌、肝癌、胰腺癌、肺癌、肾癌和膀胱癌以及非霍奇金淋巴瘤均有明显的过量。其中许多可能反映了饮酒和吸烟的影响。多次住院的患者显示出高风险,特别是食管癌(SIR 6.97)和皮肤癌(SIR 4.76)。
We examined overall and specific cancer risks among Swedish subjects who had been hospitalised one or more times for psoriasis. A database was created by identifying such patients from the Swedish Hospital Discharge Register and linking them with the Cancer Registry. Follow-up of patients was carried out from the last hospitalisation through 2004. A total of 15 858 patients were hospitalised for psoriasis during 1965–2004, of whom 1408 developed cancer, giving an overall standardised incidence ratios (SIRs) of 1.33. A significant excess was noted for squamous cell skin cancer, and for cancers of the upper aerodigestive tract, oesophagus, stomach, liver, pancreas, lung, kidney and bladder as well as non-Hodgkin lymphoma. Many of these may reflect the effects of alcohol drinking and tobacco smoking. Patients with multiple hospitalisations showed high risk, particularly for oesophageal (SIR 6.97) and skin (SIR 4.76) cancers.
DOI: 10.1016/0190-9622(93)70206-9
发表时间: 1993-09-01
影响因子: 13.8
作者:
DUFFY, DL;SPELMAN, LS;MARTIN, NG
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