Ongoing network state controls the length of sleep spindles via inhibitory activity.
Ongoing network state controls the length of sleep spindles via inhibitory activity.
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DOI：
10.1016/j.neuron.2014.04.046
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发表时间：
2014-06-18
期刊：
影响因子：
16.2
通讯作者：
Acsády L
中科院分区：
文献类型：
--
作者：
Barthó P;Slézia A;Mátyás F;Faradzs-Zade L;Ulbert I;Harris KD;Acsády L
睡眠纺锤波是哺乳动物大脑的主要瞬时振荡。脑震荡产生于丘脑;然而，目前还不清楚是什么决定了其持续时间。在这里，我们测量了兴奋性丘脑皮质（TC）细胞的体细胞活动与轴突活动的抑制性网状丘脑细胞（nRT）和量化的周期，在他们的发射在体内周期的变化。我们发现，不同持续时间的纺锤波与不同的nRT活动平行，并且在所有纺锤波终止之前，nRT放电急剧下降。初始nRT和TC活性均与纺锤体长度相关，但nRT相关性更强。由nRT的光遗传学激活诱发的纺锤体的分析表明，纺锤体的概率，而不是纺锤体的长度，是由光刺激的强度。我们的数据表明，在自然睡眠的动态波动的丘脑皮层网络控制睡眠纺锤波的持续时间，通过主要的抑制元件的电路，nRT。纺锤体终止之前nRT活性下降不同长度的纺锤体具有不同的nRT活性轨迹纺锤体持续时间受到初始网络状态的强烈影响Barthó等人。在睡眠纺锤波期间记录来自丘脑群体的耦合兴奋-抑制活动，表明正在进行的网络状态通过回路的主要抑制元件nRT控制睡眠纺锤波的长度。
Sleep spindles are major transient oscillations of the mammalian brain. Spindles are generated in the thalamus; however, what determines their duration is presently unclear. Here, we measured somatic activity of excitatory thalamocortical (TC) cells together with axonal activity of reciprocally coupled inhibitory reticular thalamic cells (nRTs) and quantified cycle-by-cycle alterations in their firing in vivo. We found that spindles with different durations were paralleled by distinct nRT activity, and nRT firing sharply dropped before the termination of all spindles. Both initial nRT and TC activity was correlated with spindle length, but nRT correlation was more robust. Analysis of spindles evoked by optogenetic activation of nRT showed that spindle probability, but not spindle length, was determined by the strength of the light stimulus. Our data indicate that during natural sleep a dynamically fluctuating thalamocortical network controls the duration of sleep spindles via the major inhibitory element of the circuits, the nRT. Coupled excitatory-inhibitory thalamic populations were recorded during spindles Spindle termination is preceded by a drop in nRT activity Spindles of different lengths have distinct nRT activity trajectories Spindle duration is strongly influenced by the initial network state Barthó et al. record coupled excitatory-inhibitory activity from thalamic populations during sleep spindles showing that ongoing network state controls the length of sleep spindles via the major inhibitory element of the circuit, the nRT.
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DOI：
10.1523/jneurosci.0077-11.2011
发表时间：
2011-06-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bonjean M;Baker T;Lemieux M;Timofeev I;Sejnowski T;Bazhenov M
通讯作者：
Bazhenov M
影响因子：
25
作者：
Cueni, Lucius;Canepari, Marco;Luthi, Anita
通讯作者：
Luthi, Anita
影响因子：
2.5
作者：
Csicsvari, J;Henze, DA;Buzsáki, G
通讯作者：
Buzsáki, G
影响因子：
5.5
作者：
BAL, T;MCCORMICK, DA
通讯作者：
MCCORMICK, DA
影响因子：
4.7
作者：
Avanzini, G;Panzica, F;de Curtis, M
通讯作者：
de Curtis, M