Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function.
Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function.
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DOI：
10.1016/j.immuni.2008.06.012
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发表时间：
2008-08-15
期刊：
影响因子：
32.4
通讯作者：
Kaye, Paul M.
中科院分区：
文献类型：
--
作者：
Maroof, Asher;Beattie, Lynette;Zubairi, Soombul;Svensson, Mattias;Stager, Simona;Kaye, Paul M.
NK细胞在早期病原体遏制和形成获得性细胞介导的免疫中发挥着公认的作用。然而，在人类和实验模型中的间接证据表明，NK细胞在慢性疾病中也起着负调节作用。为了正式检验这一假设，我们采用了一个明确的内脏利什曼病实验模型。我们的数据表明，NKp 46 + CD 49 b + CD 3- NK细胞被募集到脾脏和肝肉芽肿中，在那里它们以IL-10依赖性方式抑制宿主保护性免疫。虽然IL-10 mRNA可以在感染后24小时在活化的NK细胞中检测到，但NK细胞的抑制功能仅在感染期间后期获得，与增加的IL-10 mRNA稳定性和增强的分泌IL-10蛋白的能力一致。我们的数据支持越来越多的文献，暗示NK细胞作为细胞介导的免疫的负调节因子，并表明NK细胞，如CD 4 + Th 1细胞，可能获得免疫调节功能作为广泛激活的结果。
NK cells play a well-recognised role in early pathogen containment and in shaping acquired cell-mediated immunity. However, indirect evidence in man and experimental models has suggested that NK cells also play negative regulatory roles during chronic disease. To formally test this hypothesis, we employed a well-defined experimental model of visceral leishmaniasis. Our data demonstrate that NKp46+CD49b+CD3- NK cells are recruited to the spleen and into hepatic granulomas where they inhibit host protective immunity in an IL-10-dependent manner. Although IL-10 mRNA could be detected in activated NK cells 24h after infection, the inhibitory function of NK cells was only acquired later during infection, coincident with increased IL-10 mRNA stability and an enhanced capacity to secrete IL-10 protein. Our data support a growing body of literature that implicate NK cells as negative regulators of cell-mediated immunity and suggest that NK cells, like CD4+ Th1 cells, may acquire immunoregulatory functions as a consequence of extensive activation.
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