Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis.
Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis.
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DOI：
10.4093/dmj.2022.0129
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发表时间：
2023-05
影响因子：
5.9
通讯作者：
Han HW
中科院分区：
文献类型：
--
作者：
Kim HJ;Lee SJ;Sa S;Bae JH;Song G;Lee CW;Kim JH;Shim SR;Hong M;Han HW
对2型糖尿病(T2 DM)患者接种2019年冠状病毒病(新冠肺炎)疫苗相关的不良事件(AEs)知之甚少。本研究使用疫苗AE报告系统数据调查了接种疫苗的T2 DM患者中的严重不良反应。自然语言处理算法被应用于识别患有和不患有糖尿病的人。经过1：3匹配后，我们收集了6829名T2 DM患者和20487名健康对照的数据。采用多元Logistic回归分析计算重症急性脑血管事件的优势比。接种新冠肺炎疫苗后，T2 DM患者发生脑静脉窦血栓形成、脑炎脊髓炎、贝尔麻痹、淋巴病变、缺血性卒中、深静脉血栓形成(DVT)、血小板减少(TP)和肺栓塞(PE)等8种严重不良反应的可能性比对照组高。此外，接种BNT162b2和mRNA1273的T2 DM患者比接种JNJ-78436735疫苗的患者更容易发生深静脉血栓和TP。在接受信使核糖核酸疫苗治疗的2型糖尿病患者中，就深静脉血栓和PE的风险而言，信使核糖核酸1273比BNT162b2更安全。仔细监测T2 DM患者的严重不良反应可能是必要的，特别是对于新冠肺炎接种后与血栓形成事件和神经功能障碍相关的不良反应。
Little is known about the adverse events (AEs) associated with coronavirus disease 2019 (COVID-19) vaccination in patients with type 2 diabetes mellitus (T2DM). This study used vaccine AE reporting system data to investigate severe AEs among vaccinated patients with T2DM. A natural language processing algorithm was applied to identify people with and without diabetes. After 1:3 matching, we collected data for 6,829 patients with T2DM and 20,487 healthy controls. Multiple logistic regression analysis was used to calculate the odds ratio for severe AEs. After COVID-19 vaccination, patients with T2DM were more likely to experience eight severe AEs than controls: cerebral venous sinus thrombosis, encephalitis myelitis encephalomyelitis, Bell’s palsy, lymphadenopathy, ischemic stroke, deep vein thrombosis (DVT), thrombocytopenia (TP), and pulmonary embolism (PE). Moreover, patients with T2DM vaccinated with BNT162b2 and mRNA-1273 were more vulnerable to DVT and TP than those vaccinated with JNJ-78436735. Among patients with T2DM administered mRNA vaccines, mRNA-1273 was safer than BNT162b2 in terms of the risk of DVT and PE. Careful monitoring of severe AEs in patients with T2DM may be necessary, especially for those related to thrombotic events and neurological dysfunctions after COVID-19 vaccination.
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