Small fiber neuropathy in the cornea of Covid-19 patients associated with the generation of ocular surface disease.
Small fiber neuropathy in the cornea of Covid-19 patients associated with the generation of ocular surface disease.
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DOI：
10.1016/j.jtos.2021.10.010
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Merayo-Lloves J
中科院分区：
文献类型：
--
作者：
Barros A;Queiruga-Piñeiro J;Lozano-Sanroma J;Alcalde I;Gallar J;Fernández-Vega Cueto L;Alfonso JF;Quirós LM;Merayo-Lloves J
目的：探讨活体角膜共聚焦显微镜检测到的Sars-CoV-2感染与角膜小纤维神经病变的关系。这项观察性回顾性研究招募了23名克服COVID-19的患者。还招募了46名未感染的志愿者作为对照组进行研究。所有受试者在体内共聚焦显微镜下进行检查，获得角膜基底下神经纤维的图像，以研究神经瘤样结构、轴突束和树突状细胞的存在。以眼表疾病指数（OSDI）问卷和Schirmer泪液试验作为干眼病（DED）和眼表病理的指标。21例（91.31%）患者出现与小纤维神经病变一致的角膜基底下神经丛和角膜组织改变。健康受试者的图像未显示明显的神经纤维或角膜组织损伤。8例患者报告COVID-19感染后眼睛干涩感增加，DED指标呈阳性。82.60%的病例发现轴突呈串珠状，主要见于有眼部刺激症状的患者。65.22%的患者出现神经瘤样影像，在OSDI评分为bb0 - 13分的患者中更为常见。在69.56%的患者中发现树突状细胞，在年轻无症状患者中更常见。从Sars-CoV-2感染恢复后长达10个月的患者形态学改变的存在表明神经病变的慢性性质。Sars-CoV-2感染可能诱发眼表小纤维神经病变，与DED和糖尿病神经病变具有相同的症状和形态学标志。
To describe the association between Sars-CoV-2 infection and small fiber neuropathy in the cornea identified by in vivo corneal confocal microscopy. Twenty-three patients who had overcome COVID-19 were recruited to this observational retrospective study. Forty-six uninfected volunteers were also recruited and studied as a control group. All subjects were examined under in vivo confocal microscopy to obtain images of corneal subbasal nerve fibers in order to study the presence of neuroma-like structures, axonal beadings and dendritic cells. The Ocular Surface Disease Index (OSDI) questionnaire and Schirmer tear test were used as indicators of Dry Eye Disease (DED) and ocular surface pathology. Twenty-one patients (91.31%) presented alterations of the corneal subbasal plexus and corneal tissue consistent with small fiber neuropathy. Images from healthy subjects did not indicate significant nerve fiber or corneal tissue damage. Eight patients reported increased sensations of ocular dryness after COVID-19 infection and had positive DED indicators. Beaded axons were found in 82.60% of cases, mainly in patients reporting ocular irritation symptoms. Neuroma-like images were found in 65.22% patients, more frequently in those with OSDI scores >13. Dendritic cells were found in 69.56% of patients and were more frequent in younger asymptomatic patients. The presence of morphological alterations in patients up to 10 months after recovering from Sars-CoV-2 infection points to the chronic nature of the neuropathy. Sars-CoV-2 infection may be inducing small fiber neuropathy in the ocular surface, sharing symptomatology and morphological landmarks with DED and diabetic neuropathy.
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
影响因子：
4.1
作者：
Al-Aqaba, Mouhamed A.;Fares, Usama;Dua, Harminder S.
通讯作者：
Dua, Harminder S.
DOI：
10.1136/bjophthalmol-2021-319450
发表时间：
2022-12
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Bitirgen G;Korkmaz C;Zamani A;Ozkagnici A;Zengin N;Ponirakis G;Malik RA
通讯作者：
Malik RA
DOI：
10.1109/tbme.2016.2573642
发表时间：
2017-04
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Chen X;Graham J;Dabbah MA;Petropoulos IN;Tavakoli M;Malik RA
通讯作者：
Malik RA
DOI：
10.1016/j.jtos.2016.09.004
发表时间：
2017-01
期刊：
The ocular surface
影响因子：
--
作者：
Cruzat A;Qazi Y;Hamrah P
通讯作者：
Hamrah P