A nonlinear relationship between visceral adipose tissue and frailty in adult lung transplant candidates.
A nonlinear relationship between visceral adipose tissue and frailty in adult lung transplant candidates.
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成人肺移植候选物中内脏脂肪组织与脆弱的非线性关系。
DOI：
10.1111/ajt.15525
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发表时间：
2019-11
期刊：
影响因子：
--
通讯作者：
Singer JP
中科院分区：
文献类型：
--
作者：
Anderson MR;Kolaitis NA;Gao Y;Kukreja J;Greenland J;Hays S;Wolters P;Golden J;Diamond J;Palmer S;Arcasoy S;Udupa J;Christie JD;Lederer DJ;Singer JP
虚弱是一种生理储备下降的状态，与肺移植前后的不良结果相关。肥胖，特别是以过量促炎性内脏脂肪组织（VAT）为特征的向心性肥胖，与中老年人的身体虚弱有关。然而，增值税与晚期肺病虚弱之间的关联尚不清楚。在两个非重叠的多中心成人肺移植队列中，我们在一个队列中通过生物电阻抗测定（BIA）测量了 VAT 面积，在另一队列中通过腹部计算机断层扫描（CT）测量了横截面 VAT 和皮下脂肪组织（SAT）面积。我们发现 BIA 增加的增值税与虚弱之间存在非线性关系。在完全调整的分段回归模型中，VAT 面积每增加 20 cm2，高 VAT 受试者的虚弱几率增加 50%（95% CI 1.2-1.9，P < .001），而低 VAT 受试者的虚弱几率降低 10%（95% CI 0.7-1.04，P = .12）。与增值税较低的虚弱受试者相比，增值税较高的人更有可能握力较低，并且体重减轻的可能性较小，这表明虚弱的机制可能因增值税而异。进一步研究增值税与虚弱之间的联系机制可能会确定新的预防和治疗目标。
Frailty is a state of decreased physiologic reserve associated with poor outcomes before and after lung transplantation. Obesity, particularly central obesity characterized by excess proinflammatory visceral adipose tissue (VAT), is associated with incident frailty in middle-aged and older adults. The association between VAT and frailty in advanced lung disease, however, is unknown. In two, nonoverlapping multicenter cohorts of adults listed for lung transplantation, we measured VAT area on bioelectrical impedance assay (BIA) in one cohort and cross-sectional VAT and subcutaneous adipose tissue (SAT) areas on abdominal computed tomography (CT) in the other. We identified a nonlinear relationship between greater VAT by BIA and frailty. In fully adjusted piecewise regression models, every 20 cm2 increase in VAT area was associated with 50% increased odds of frailty in subjects with high VAT (95% CI 1.2–1.9, P < .001), and 10% decreased odds of frailty (95% CI 0.7–1.04, P = .12) in subjects with low VAT. Compared to frail subjects with low VAT, those with high VAT were more likely to have low grip strength and less likely to have weight loss, suggesting that mechanisms of frailty may differ by VAT. Further investigation of mechanisms linking VAT and frailty may identify new targets for prevention and treatment.
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影响因子：
8.8
作者：
Singer, Jonathan P.;Diamond, Joshua M.;Lederer, David J.
通讯作者：
Lederer, David J.
影响因子：
2.1
作者：
Berker, Dilek;Koparal, Sueha;Guler, Serdar
通讯作者：
Guler, Serdar
腹部肥胖，肌肉减少症和骨质疏松症与患有和没有艾滋病毒的男性的男性脆弱有关。
DOI：
10.1097/qad.0000000000001829
发表时间：
2018-06-19
期刊：
AIDS (London, England)
影响因子：
--
作者：
Hawkins KL;Zhang L;Ng DK;Althoff KN;Palella FJ Jr;Kingsley LA;Jacobson LP;Margolick JB;Lake JE;Brown TT;Erlandson KM
通讯作者：
Erlandson KM
DOI：
10.1093/gerona/glt052
发表时间：
2014-01-01
影响因子：
5.1
作者：
Stenholm, Sari;Strandberg, Timo E.;Koskinen, Seppo
通讯作者：
Koskinen, Seppo
影响因子：
11.1
作者：
Justice, Jamie N.;Nambiar, Anoop M.;Kirkland, James L.
通讯作者：
Kirkland, James L.