An assay for social interaction in Drosophila fragile X mutants.
An assay for social interaction in Drosophila fragile X mutants.
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作者：
Bolduc FV;Valente D;Nguyen AT;Mitra PP;Tully T
我们开发了一种新的检测方法来检测果蝇的社会互动，并作为第一次尝试，将其应用于检测果蝇脆性X智力发育迟滞基因（dfmr1）突变体的行为。脆性X染色体综合征是单基因智力残疾（ID）的最常见原因，通常与自闭症有关。我们的研究结果表明，dfmr1突变体比野生型果蝇活性更低，相互作用的频率也更低。此外，dfmr1的一个等位基因dfmr1B55的突变体比另一个dfmr1B55突变体更有可能与野生型苍蝇密切接触。我们的研究结果提出了保留接受能力的社会表达缺陷的可能性。我们进一步建议，该分析可能应用于检查果蝇复杂人类神经系统疾病的一般策略，特别是为了了解与ID相关的社会互动缺陷的遗传基础。
We developed a novel assay to examine social interactions in Drosophila and, as a first attempt, apply it here at examining the behavior of Drosophila Fragile X Mental Retardation gene (dfmr1) mutants. Fragile X syndrome is the most common cause of single gene intellectual disability (ID) and is frequently associated with autism. Our results suggest that dfmr1 mutants are less active than wild-type flies and interact with each other less often. In addition, mutants for one allele of dfmr1, dfmr1B55, are more likely to come in close contact with a wild-type fly than another dfmr1B55 mutant. Our results raise the possibility of defective social expression with preserved receptive abilities. We further suggest that the assay may be applied in a general strategy of examining endophenoypes of complex human neurological disorders in Drosophila, and specifically in order to understand the genetic basis of social interaction defects linked with ID.
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