Simultaneous activation of multiple vestibular pathways upon electrical stimulation of semicircular canal afferents.
Simultaneous activation of multiple vestibular pathways upon electrical stimulation of semicircular canal afferents.
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DOI：
10.1007/s00415-020-10120-1
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发表时间：
2020-12
影响因子：
6
通讯作者：
Pérez Fornos A
中科院分区：
文献类型：
--
作者：
Boutabla A;Cavuscens S;Ranieri M;Crétallaz C;Kingma H;van de Berg R;Guinand N;Pérez Fornos A
前庭植入物似乎是一个有前途的治疗患有严重的双侧前庭病变的患者。为了优化结果，我们需要研究如何以及在何种程度上激活不同的前庭通路。在这里，我们的特点是同时响应三个不同的前庭通路的电刺激。包括三个前庭植入受体。首先，通过5个不同的前庭电极，记录电诱发前庭-眼反射（eVOR）、颈肌源性电位（ecVEMP）和前庭感知（前庭-丘脑-皮层，VTC）的激活阈值和幅度增长函数。还表征了eVOR和ecVEMP的发光。然后，我们在一名患者（两个电极）中使用不同的刺激曲线（1脉冲，200 µs/相位; 1脉冲，50 µs/相位; 4脉冲，50 µs/相位，每秒1600个脉冲）比较了三种途径的幅度增长函数。eVOR和ecVEMP的中位延迟分别为8 ms（8-9 ms）和10.2 ms（9.6-11.8 ms）。虽然eVOR和ecVEMP反应的幅度随着刺激电流的增加而增加，但VTC通路显示出不同的阶梯状行为。在本研究中，200 µs/相位模式似乎提供了最佳平衡，以增强较低刺激电流下的反应。这项研究是第一次尝试，以评估同时激活不同的前庭通路。然而，这个问题值得进一步和更详细的调查，以确定一个给定的路径的选择性刺激的实际可能性，以及每个路径的贡献的整体康复过程的功能影响。
Vestibular implants seem to be a promising treatment for patients suffering from severe bilateral vestibulopathy. To optimize outcomes, we need to investigate how, and to which extent, the different vestibular pathways are activated. Here we characterized the simultaneous responses to electrical stimuli of three different vestibular pathways. Three vestibular implant recipients were included. First, activation thresholds and amplitude growth functions of electrically evoked vestibulo-ocular reflexes (eVOR), cervical myogenic potentials (ecVEMPs) and vestibular percepts (vestibulo-thalamo-cortical, VTC) were recorded upon stimulation with single, biphasic current pulses (200 µs/phase) delivered through five different vestibular electrodes. Latencies of eVOR and ecVEMPs were also characterized. Then we compared the amplitude growth functions of the three pathways using different stimulation profiles (1-pulse, 200 µs/phase; 1-pulse, 50 µs/phase; 4-pulses, 50 µs/phase, 1600 pulses-per-second) in one patient (two electrodes). The median latencies of the eVOR and ecVEMPs were 8 ms (8–9 ms) and 10.2 ms (9.6–11.8 ms), respectively. While the amplitude of eVOR and ecVEMP responses increased with increasing stimulation current, the VTC pathway showed a different, step-like behavior. In this study, the 200 µs/phase paradigm appeared to give the best balance to enhance responses at lower stimulation currents. This study is a first attempt to evaluate the simultaneous activation of different vestibular pathways. However, this issue deserves further and more detailed investigation to determine the actual possibility of selective stimulation of a given pathway, as well as the functional impact of the contribution of each pathway to the overall rehabilitation process.
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DOI：
10.1159/000433554
发表时间：
2015-01-01
影响因子：
1.3
作者：
Guinand, Nils;van de Berg, Raymond;Perez-Fornos, Angelica
通讯作者：
Perez-Fornos, Angelica
DOI：
10.1007/s10162-013-0413-0
发表时间：
2013-12-01
影响因子：
2.4
作者：
Dai, Chenkai;Fridman, Gene Y.;Della Santina, Charles C.
通讯作者：
Della Santina, Charles C.
影响因子：
1.4
作者：
Guinand, Nils;Boselie, Frans;Kingma, Herman
通讯作者：
Kingma, Herman
影响因子：
2.5
作者：
BAIRD, RA;DESMADRYL, G;GOLDBERG, JM
通讯作者：
GOLDBERG, JM
影响因子：
2.5
作者：
Collewijn, H;Smeets, JBJ
通讯作者：
Smeets, JBJ