Shifting from fear to safety through deconditioning-update
Shifting from fear to safety through deconditioning-update
复制标题
通过去调节更新从恐惧转向安全
DOI：
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
L. de Oliveira Alvares
中科院分区：
文献类型：
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作者：
Bruno Popik;F. E. Amorim;O. Amaral;L. de Oliveira Alvares
厌恶记忆是恐惧症和创伤后应激障碍（PTSD）等精神疾病的核心。在这里，我们提出了一种新的老鼠行为方法，可以大大减弱厌恶记忆。这种方法包括对先前训练过的动物进行“去适应”，将一种音调与强烈的足部电击联系起来，在记忆检索过程中用一种更弱的音调代替它。我们的结果表明，去条件化更新在减少恐惧反应方面比传统的灭绝更有效。此外，这种影响是持久的，难以更新和自然恢复。值得注意的是，这种策略克服了记忆更新的重要边界条件，例如遥远的或非常强烈的创伤记忆。在其他类型的与恐惧相关的记忆中也发现了同样的有益效果。去条件化是由 L 型电压门控钙通道介导的，并且与不匹配引起的记忆更新的计算结果一致。我们的结果表明，通过去条件化更新从恐惧转向安全是减轻创伤记忆的一种有前途的方法。
Aversive memories are at the heart of psychiatric disorders such as phobias and post-traumatic stress disorder (PTSD). Here, we present a new behavioral approach in rats that robustly attenuates aversive memories. This method consists of “deconditioning” animals previously trained to associate a tone with a strong footshock by replacing it with a much weaker one during memory retrieval. Our results indicate that deconditioning-update is more effective than traditional extinction in reducing fear responses; moreover, such effects are long lasting and resistant to renewal and spontaneous recovery. Remarkably, this strategy overcame important boundary conditions for memory updating, such as remote or very strong traumatic memories. The same beneficial effect was found in other types of fear-related memories. Deconditioning was mediated by L-type voltage-gated calcium channels and is consistent with computational accounts of mismatch-induced memory updating. Our results suggest that shifting from fear to safety through deconditioning-update is a promising approach to attenuate traumatic memories.
影响因子：
22.4
作者：
Kredlow MA;Unger LD;Otto MW
通讯作者：
Otto MW
影响因子：
3.4
作者：
Auber, Alessia;Tedesco, Vincenzo;Jones, Carolyn E.;Monfils, Marie-H.;Chiamulera, Christian
通讯作者：
Chiamulera, Christian