Post-retrieval extinction as reconsolidation interference: methodological issues or boundary conditions?
Post-retrieval extinction as reconsolidation interference: methodological issues or boundary conditions?
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DOI：
10.1007/s00213-013-3004-1
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发表时间：
2013-04
影响因子：
3.4
通讯作者：
Chiamulera, Christian
中科院分区：
文献类型：
--
作者：
Auber, Alessia;Tedesco, Vincenzo;Jones, Carolyn E.;Monfils, Marie-H.;Chiamulera, Christian
唤起情感的记忆通常会促进物种的生存;然而，调节情感学习的系统可能会出错，导致创伤后应激障碍、恐惧症和成瘾等病理状态。了解情绪记忆可以被靶向的条件是一个主要的研究重点，因为将这些方法转化为临床人群的潜力具有重要意义。已经证明，与恐惧和毒品有关的记忆在恢复时都会不稳定，需要重新巩固才能维持。因此，记忆再巩固提供了一个潜在的目标时期，在此期间，精神疾病的异常记忆可以被破坏。 第一次表明，通过提取后的消退阶段（在重新巩固窗口期间）提供的安全信息可能会更新原始记忆痕迹，并防止大鼠再次出现恐惧。近年来，一些作者在实验室动物和人类中测试了提取后消退对恐惧或药物相关记忆重新巩固的影响。在这篇文章中，我们回顾了有关复活后灭绝的文献，讨论了方法学基础上的研究差异，并回顾了可能解释现有差异并限制复活后灭绝方法潜在应用的潜在边界条件。
Memories that are emotionally arousing generally promote the survival of species; however, the systems that modulate emotional learning can go awry, resulting in pathological conditions such as post-traumatic stress disorders, phobias, and addiction. Understanding the conditions under which emotional memories can be targeted is a major research focus as the potential to translate these methods into clinical populations carries important implications. It has been demonstrated that both fear and drug-related memories can be destabilised at their retrieval and require reconsolidation to be maintained. Therefore, memory reconsolidation offers a potential target period during which the aberrant memories underlying psychiatric disorders can be disrupted. have shown for the first time that safe information provided through an extinction session after retrieval (during the reconsolidation window) may update the original memory trace and prevent the return of fear in rats. In recent years several authors have then tested the effect of post-retrieval extinction on reconsolidation of either fear or drug related memories in both laboratory animals and humans. In this article we review the literature on post-reactivation extinction, discuss the differences across studies on the methodological ground, and review the potential boundary conditions that may explain existing discrepancies and limit the potential application of post-reactivation extinction approaches.
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