Impaired spermatogenesis is not an obligate expression of receptor-defective androgen resistance.
Impaired spermatogenesis is not an obligate expression of receptor-defective androgen resistance.
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精子发生受损并不是受体缺陷型雄激素抵抗的必然表现。
DOI：
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
D. Killinger
中科院分区：
文献类型：
--
作者：
L. Pinsky;M. Kaufman;D. Killinger
We are studying a man who presented at age 21 years with severe extragenital subvirilization despite high-normal to above-normal levels of plasma testosterone for at least 5 years. At puberty, his penis, scrotum, and testes matured normally, and he did not develop gynecomastia; however, his voice, muscularity, and facial, sexual, and body hair remained immature. A 2.5-ml ejaculate yielded normal results for sperm density, morphology, and motility. Because persistent undervirilization was emotionally disabling, he has received pharmacologic doses of testosterone enanthate intramuscularly for 3.5 years. The treatment has improved his virilization and masculine self-image substantially, and his semen analysis has remained well within the normal range. The androgen receptor in his genital skin fibroblasts has a distinctively mutant phenotype: it has a low affinity (increased apparent equilibrium dissociation constant, Kd) for 5 alpha-dihydrotestosterone and two synthetic androgens, mibolerone (MB) and methyltrienolone (MT), and its binding capacity (Bmax) is normal for the other two ligands, but questionably low for MT. In addition, it up-regulates its activity normally in response to prolonged incubation with androgen, and its androgen-receptor complexes are not thermolabile. Our study of this man permits two conclusions: impaired spermatogenesis is not the irreducible expression of receptor-defective androgen resistance in man; and androgen pharmacotherapy may be remedial for those in whom extragenital subvirilization is emotionally costly and subnormal spermatogenesis is not an inevitable side effect of such therapy.
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DOI：
10.1210/jcem-55-3-465
发表时间：
1982-09
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
James E. Griffin;Joy L. Durrant
通讯作者：
James E. Griffin;Joy L. Durrant
轻度雄激素不敏感的临床综合征。
DOI：
10.1210/jcem-59-4-672
发表时间：
1984
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Migeon,CJ;Brown,TR;Lanes,R;Palacios,A;Amrhein,JA;Schoen,EJ
通讯作者：
Schoen,EJ
影响因子：
56.9
作者：
LUBAHN, DB;JOSEPH, DR;WILSON, EM
通讯作者：
WILSON, EM
由于 5α-还原酶缺乏和雄激素受体紊乱引起的男性假两性畸形的高剂量雄激素治疗。
DOI：
10.1172/jci111563
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Price,P;Wass,JA;Griffin,JE;Leshin,M;Savage,MO;Large,DM;Bu'Lock,DE;Anderson,DC;Wilson,JD;Besser,GM
通讯作者：
Besser,GM
促进糖皮质激素受体与DNA结合的热稳定胞质因子既不是硫氧还蛋白也不是核糖核酸酶。
DOI：
10.1016/0022-4731(87)90501-2
发表时间：
1987
期刊：
Journal of steroid biochemistry
影响因子：
--
作者：
Tienrungroj,W;Pratt,SE;Grippo,JF;Holmgren,A;Pratt,WB
通讯作者：
Pratt,WB