Stable behavioral inhibition and glucocorticoid production as predictors of longevity.
Stable behavioral inhibition and glucocorticoid production as predictors of longevity.
复制标题
稳定的行为抑制和糖皮质激素的产生作为寿命的预测指标。
DOI：
10.1016/j.physbeh.2009.05.012
复制
发表时间：
2009-08-04
影响因子：
2.9
通讯作者：
Bruscke AP
中科院分区：
文献类型：
--
作者：
Cavigelli SA;Ragan CM;Michael KC;Kovacsics CE;Bruscke AP
一些性格/气质特征与人类和动物的健康结果有关，但对这些不同结果的潜在生理机制知之甚少。在本文中，我们比较了行为特征（行为抑制）和相关生理特征（糖皮质激素产生）在预测寿命方面的强度。此外，我们还研究了个体在成年的很大一部分时间里行为和生理特征的相对稳定性，并检验了稳定的行为特征与稳定的生理偏差相关的假设。在 60 只 Sprague-Dawley 雄性大鼠的样本中，我们发现稳定的抑制/新恐惧症比稳定升高的糖皮质激素分泌更能预测寿命。此外，这些预测因素似乎对寿命有附加影响，因为具有两种危险因素（稳定抑制和持续高糖皮质激素产生）的男性的寿命最短，表明这两个特征都是寿命的重要预测因素。在成年早期的 4 个月期间，抑制和糖皮质激素反应性是相对稳定的特征，但这两个特征彼此之间的相关性并不高。有趣的是，基线糖皮质激素的产生比反应水平更能预测寿命。结果表明，成年早期糖皮质激素的产生是寿命的重要预测因素，尽管其预测作用不如抑制作用那么强，并且其他生理过程可能进一步解释行为抑制个体的寿命缩短。
Several personality/temperament traits have been linked to health outcomes in humans and animals but underlying physiological mechanisms for these differential outcomes are minimally understood. In this paper, we compared the strength of a behavioral trait (behavioral inhibition) and an associated physiological trait (glucocorticoid production) in predicting life span. In addition, we examined the relative stability of both the behavioral and physiological trait within individuals over a significant portion of adulthood, and tested the hypothesis that a stable behavioral trait is linked with a stable physiological bias. In a sample of 60 Sprague-Dawley male rats, we found that stable inhibition/neophobia was a stronger predictor of life span than stably elevated glucocorticoid production. In addition, these predictors appeared to have an additive influence on life span in that males with both risk factors (stable inhibition and consistently high glucocorticoid production) had the shortest life spans of all, suggesting both traits are important predictors of life span. Across a 4-month period in young adulthood, inhibition and glucocorticoid reactivity were relatively stable traits, however these two traits were not highly correlated with one another. Interestingly, baseline glucocorticoid production was a better predictor of life span than reactivity levels. The results indicate that glucocorticoid production in young adulthood is an important predictor of life span, although not as strong a predictor as inhibition, and that other physiological processes may further explain the shortened life span in behaviorally-inhibited individuals.
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DOI：
10.1037/h0057198
发表时间：
1949-01-01
期刊：
JOURNAL OF ABNORMAL AND SOCIAL PSYCHOLOGY
影响因子：
--
作者：
FISKE, DW
通讯作者：
FISKE, DW
影响因子：
3.3
作者：
Fediuc, Sergiu;Campbell, Jonathan E.;Riddell, Michael C.
通讯作者：
Riddell, Michael C.
影响因子：
4.7
作者：
Carmelli, D;Swan, GE
通讯作者：
Swan, GE
影响因子：
3.3
作者：
Costantini, David;Carere, Claudio;Koolhaas, Jaap M.
通讯作者：
Koolhaas, Jaap M.
影响因子：
4.8
作者：
Atkinson, HC;Waddell, BJ
通讯作者：
Waddell, BJ