Epithelial discrimination of commensal and pathogenic Candida albicans.
Epithelial discrimination of commensal and pathogenic Candida albicans.
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共生和致病性白色念珠菌的上皮细胞辨别。
作者：
Tang SX
所有粘膜表面都衬有上皮细胞，并被机会性微生物定殖。在健康的情况下，这些机会性微生物仍然存在，并被免疫系统所耐受。然而，当正确的环境条件出现时，这些微生物可能会变得致病，需要由免疫系统控制或清除以预防疾病。使上皮细胞能够启动由病原微生物特异性激活的“危险”信号的机制对粘膜防御和体内平衡至关重要，但尚未得到很好的理解。破译这些机制将为理解粘膜组织如何维持健康和激活免疫力以及病原体如何促进疾病提供必要的帮助。本文综述了人类真菌病原体白色念珠菌与上皮细胞的相互作用，以及使粘膜组织能够区分这种医学上重要的真菌的侵袭性和致病性状态的上皮机制。
All mucosal surfaces are lined by epithelial cells and are colonised by opportunistic microbes. In health, these opportunistic microbes remain commensal and are tolerated by the immune system. However, when the correct environmental conditions arise, these microbes can become pathogenic and need to be controlled or cleared by the immune system to prevent disease. The mechanisms that enable epithelial cells to initiate the ‘danger’ signals activated specifically by pathogenic microbes are critical to mucosal defence and homeostasis but are not well understood. Deciphering these mechanisms will provide essential understanding to how mucosal tissues maintain health and activate immunity, as well as how pathogens promote disease. This review focuses on the interaction of the human fungal pathogenCandida albicanswith epithelial cells and the epithelial mechanisms that enable mucosal tissues to discriminate between the commensal and pathogenic state of this medically important fungus.
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影响因子：
56.9
作者：
Staab, JF;Bradway, SD;Sundstrom, P
通讯作者：
Sundstrom, P
影响因子：
4.4
作者：
Pivarcsi, A;Bodai, L;Kemény, L
通讯作者：
Kemény, L
白色念珠菌诱导口腔上皮细胞早期凋亡，随后继发性坏死。
影响因子：
3.7
作者：
Villar,CC;Zhao,XR
通讯作者：
Zhao,XR
影响因子：
3.8
作者：
Yano, Junko;Noverr, Mairi C.;Fidel, Paul L., Jr.
通讯作者：
Fidel, Paul L., Jr.
影响因子：
30.3
作者：
Hernández-Santos N;Gaffen SL
通讯作者：
Gaffen SL