Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans.
Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans.
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DOI：
10.1111/j.1365-2265.2009.03676.x
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发表时间：
2010-05
影响因子：
3.2
通讯作者：
Flack JM
中科院分区：
文献类型：
--
作者：
Valiña-Tóth AL;Lai Z;Yoo W;Abou-Samra A;Gadegbeku CA;Flack JM
肥胖不成比例地影响非洲裔美国人（AA）（特别是女性），并与抑郁的25-羟基维生素D（25-OH D）和甲状旁腺激素（PTH）升高有关。AA患者25-OH D和PTH与身体组成和体型的关系尚不清楚。目的探讨25-羟维生素D和甲状旁腺素水平与人体成分和人体测量指标的关系。在98名健康、超重、成人AA中进行了一项横断面研究，这些AA参加了NIH/NIEHS赞助的体重减轻/盐敏感性研究。采用多元线性回归分析探讨25-OH D和PTH与身体成分的关系，通过双能X线吸收测定法和人体测量。使用一般线性模型在维生素D/PTH组之间比较身体组成和大小：1）正常（25-OH D> 50 nmol/l，PTH ≤ 65 pg/ml），2）低25-OH D和正常PTH，以及3）低25-OH D和高PTH。年龄、性别和季节调整回归分析显示，PTH与总脂肪量（p = 0.02）、躯干脂肪量（p = 0.03）和四肢脂肪量（p = 0.03）直接相关，而25-OH D与躯干脂肪量（p = 0.02）负相关。第1 - 3组的总脂肪量分别为30.0、34.0至37.4 kg（p = 0.008）;躯干脂肪量为13.4、15.9和17.6 kg（p = 0.006），四肢脂肪量为15.8、16.9和19.7 kg（p = 0.02）。3组间的瘦体重没有差异。我们的研究结果表明，较低的25-OH D和升高的PTH都与成人AA的脂肪量，脂肪分布和人体测量指标相关，但方向相反。
Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH to body composition and size in AA is not well known. To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures. A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt sensitivity. Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: 1) normal (25-OH D > 50 nmol/l, PTH ≤ 65 pg/ml), 2) low 25-OH D and normal PTH, and 3) low 25-OH D and high PTH. Age, sex and season-adjusted regression analyses showed that PTH was directly correlated with total (p=0.02), truncal (p=0.03) and extremity (p=0.03) fat mass while 25-OH D was related inversely to truncal fat mass (p=0.02). Total fat mass in groups 1–3, respectively, was 30.0, 34.0, to 37.4 kg (p=0.008); truncal fat mass was 13.4, 15.9 and 17.6 kg (p=0.006) and extremity fat mass was 15.8, 16.9 and 19.7 kg (p=0.02). Lean mass did not differ across the 3 groups. Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.
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影响因子：
120.7
作者：
Hedley, AA;Ogden, CL;Flegal, KM
通讯作者：
Flegal, KM
DOI：
10.1016/j.jsbmb.2008.09.006
发表时间：
2008-11
影响因子：
4.1
作者：
Li, Jia;Byrne, Mary E.;Chang, Eugene;Jiang, Yan;Donkin, Shawn S.;Buhman, Kimberly K.;Burgess, John R.;Teegarden, Dorothy
通讯作者：
Teegarden, Dorothy
影响因子：
7.1
作者：
Nesby-O'Dell, S;Scanlon, KS;Bowman, BA
通讯作者：
Bowman, BA
DOI：
10.1016/j.jsbmb.2006.12.078
发表时间：
2007-03-01
影响因子：
4.1
作者：
Hewison, Martin;Burke, Fiona;Adams, John S.
通讯作者：
Adams, John S.
DOI：
10.1159/000057442
发表时间：
1999-05-01
期刊：
MINERAL AND ELECTROLYTE METABOLISM
影响因子：
--
作者：
Bikle, DD;Ettinger, B;Tolan, K
通讯作者：
Tolan, K