The novel seizure quality index for the antidepressant outcome prediction in electroconvulsive therapy: association with biomarkers in the cerebrospinal fluid
The novel seizure quality index for the antidepressant outcome prediction in electroconvulsive therapy: association with biomarkers in the cerebrospinal fluid
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电惊厥治疗中抗抑郁结果预测的新型癫痫发作质量指数：与脑脊液中生物标志物的关联
DOI：
10.1007/s00406-019-01086-x
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发表时间：
2019
影响因子：
4.7
通讯作者：
Sartorius A
中科院分区：
文献类型：
--
作者：
Kranaster L;Hoyer C;Mindt S;Neumaier M;Müller N;Zill P;Schwarz MJ;Moll N;Lutz B;Bindila L;Zerr I;Schmitz M;Blennow K;Zetterberg H;Haffner D;Leifheit-Nestler M;Ozbalci;Sartorius A
对于接受电休克治疗（ECT）的抑郁症患者，新的癫痫发作质量指数（SQI）可以预测无应答（和无缓解）的风险-早在第二次ECT治疗后-基于癫痫发作的几个发作参数的程度。我们的目的是测试几种CSF标记物预测癫痫发作质量程度的能力，通过SQI测量，以确定可能的因素，这可以解释癫痫发作质量的一些变化。在ECT之前测量抑郁症患者（n= 12）的犬尿氨酸途径代谢物、神经变性标志物（tau蛋白、β-淀粉样蛋白和神经颗粒蛋白）、先天免疫系统元素、内源性大麻素、鞘脂、神经营养因子（VEGF）和Klotho的基线CSF水平，以通过Pearson偏相关性确定与SQI的可能相关性。观察到T-tau（rpartial= − 0.69，p = 0.019）、磷脂酰胆碱（rpartial= − 0.52，p = 0.038）和IL-8（rpartial= − 0.67，p = 0.047）的CSF水平与应答SQI呈负线性关系。关于缓解的SQI，内源性大麻素AEA（rpartial=-0.70，p = 0.024）和CD 163（rpartial=-0.68，p = 0.029）的CSF水平与SQI呈负线性关系。总之，发现先天免疫系统、神经变性和脂质的CSF标志物与调整年龄后应答和缓解的SQI相关。一致地，较高的CSF标记物水平总是与较低的癫痫发作质量相关。基于这些结果，建议进一步研究ECT中癫痫发作质量的机制。
For patients with depression treated with electroconvulsive therapy (ECT), the novel seizure quality index (SQI) can predict the risk of non-response (and non-remission)—as early as after the second ECT session—based the extent of several ictal parameters of the seizure. We aim to test several CSF markers on their ability to predict the degree of seizure quality, measured by the SQI to identify possible factors, that could explain some variability of the seizure quality. Baseline CSF levels of metabolites from the kynurenine pathway, markers of neurodegeneration (tau proteins, β-amyloids and neurogranin), elements of the innate immune system, endocannabinoids, sphingolipids, neurotrophic factors (VEGF) and Klotho were measured before ECT in patients with depression (n= 12) to identify possible correlations with the SQI by Pearson's partial correlation. Negative, linear relationships with the SQI for response were observed for CSF levels of T-tau (rpartial= − 0.69,p= 0.019), phosphatidylcholines (rpartial= − 0.52,p= 0.038) and IL-8 (rpartial= − 0.67,p= 0.047). Regarding the SQI for remission, a negative, linear relationship was noted with CSF levels of the endocannabinoid AEA (rpartial= − 0.70,p= 0.024) and CD163 (rpartial= − 0.68,p= 0.029). In sum, CSF Markers for the innate immune system, for neurodegeneration and from lipids were found to be associated with the SQI for response and remission after adjusting for age. Consistently, higher CSF levels of the markers were always associated with lower seizure quality. Based on these results, further research regarding the mechanism of seizure quality in ECT is suggested.
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